Journal ArticleDOI
Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series
James V. Guarrera,Scot D. Henry,Benjamin Samstein,R. Odeh‐Ramadan,M. Kinkhabwala,Michael J. Goldstein,Lloyd E. Ratner,John F. Renz,H. T. Lee,Robert S. Brown,Jean C. Emond +10 more
TLDR
HMP of donor livers provided safe and reliable preservation in this pilot case‐controlled series and further multicenter HMP trials are now warranted.About:
This article is published in American Journal of Transplantation.The article was published on 2010-02-01. It has received 480 citations till now. The article focuses on the topics: Transplantation & Machine perfusion.read more
Citations
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Journal ArticleDOI
Ischaemia-reperfusion injury in liver transplantation--from bench to bedside.
TL;DR: The latest mechanistic insights into innate–adaptive immune crosstalk and cell activation cascades that lead to inflammation-mediated injury in livers stressed by ischaemia–reperfusion are highlighted, progress in large animal experiments is discussed and efforts to minimize liver IRI in patients who have received a liver transplant are examined.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
The promise of organ and tissue preservation to transform medicine
Sebastian Giwa,Jedediah K. Lewis,Luis M. Alvarez,Luis M. Alvarez,Luis M. Alvarez,Robert Langer,Alvin E. Roth,George M. Church,James F. Markmann,David H. Sachs,Anil Chandraker,Anil Chandraker,Jason A. Wertheim,Martine Rothblatt,Edward S. Boyden,Elling Eidbo,W. P. Andrew Lee,Bohdan Pomahac,Gerald Brandacher,David M. Weinstock,Gloria D. Elliott,David R. Nelson,Jason P. Acker,Korkut Uygun,Boris Schmalz,Boris Schmalz,Brad P Weegman,Alessandro Tocchio,Greg M Fahy,Kenneth B. Storey,Boris Rubinsky,John C. Bischof,Janet A.W. Elliott,Teresa K. Woodruff,G. John Morris,Utkan Demirci,Kelvin G. M. Brockbank,Erik J. Woods,Robert N. Ben,John G. Baust,Dayong Gao,Barry Fuller,Yoed Rabin,David C. Kravitz,Michael J. Taylor,Michael J. Taylor,Mehmet Toner +46 more
TL;DR: Developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research.
Journal ArticleDOI
First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.
Philipp Dutkowski,Wojciech G. Polak,Paolo Muiesan,Andrea Schlegel,Cornelia J. Verhoeven,Irene Scalera,Michelle L. DeOliveira,Philipp Kron,Pierre-Alain Clavien +8 more
TL;DR: No graft failure due to intrahepatic cholangiopathy or nonfunction occurred in HOPE-treated livers, whereas 18% of unperfused DCD livers needed retransplantation.
Journal ArticleDOI
HOPE for human liver grafts obtained from donors after cardiac death.
Philipp Dutkowski,Andrea Schlegel,Michelle L. de Oliveira,Beat Müllhaupt,Fabienne Neff,Pierre-Alain Clavien +5 more
TL;DR: This is the first report on cold machine perfusion of human liver grafts obtained after cardiac arrest and subsequent transplantation and application of HOPE appears well tolerated, easy-to-use, and protective against early and later injuries.
References
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Journal ArticleDOI
Risk factors for primary dysfunction after liver transplantation--a multivariate analysis.
Rutger J. Ploeg,Anthony M. D'Alessandro,Stuart J. Knechtle,Mark D. Stegall,John D. Pirsch,Robert M. Hoffmann,Truman M. Sasaki,Hans W. Sollinger,Belzer Fo,Munci Kalayoglu +9 more
TL;DR: Routine donor liver biopsies are recommended to decrease the rate of IPF and PNF, and the combination of risk factors shown to be significant for PDF should be avoided--and the only variable that can be controlled, the preservation time, should be kept as short as possible.
Journal ArticleDOI
Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
Cyril Moers,Jacqueline M. Smits,Mark-Hugo J. Maathuis,Juergen Treckmann,Frank Van Gelder,Bogdan P. Napieralski,Margitta van Kasterop-Kutz,Jaap J. Homan van der Heide,Jean-Paul Squifflet,Ernest van Heurn,Guenter R. Kirste,Axel Rahmel,Henri G. D. Leuvenink,Andreas Paul,Jacques Pirenne,Rutger J. Ploeg +15 more
TL;DR: Hypothermic machine perfusion was associated with a reduced risk of delayed graft function and improved graft survival in the first year after transplantation.
Journal ArticleDOI
Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation THE AUTHORS REPLY
Journal ArticleDOI
Early allograft dysfunction after liver transplantation: a definition and predictors of outcome. National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database.
TL;DR: Recipients who develop EAD have longer ICU and hospital stays and greater mortality than those without and a logistic regression model combining donor, graft, and recipient factors predicted EAD better than models examining these factors in isolation.
Journal ArticleDOI
Liver and kidney preservation by perfusion
TL;DR: There is good evidence that preservation times will be extended by the provision of continuous cellular substrate, and use of non-heart-beating donors, international organ sharing, and precise calculation of the risk of primary organ failure could become standard.
Related Papers (5)
Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation
Cyril Moers,Jacqueline M. Smits,Mark-Hugo J. Maathuis,Juergen Treckmann,Frank Van Gelder,Bogdan P. Napieralski,Margitta van Kasterop-Kutz,Jaap J. Homan van der Heide,Jean-Paul Squifflet,Ernest van Heurn,Guenter R. Kirste,Axel Rahmel,Henri G. D. Leuvenink,Andreas Paul,Jacques Pirenne,Rutger J. Ploeg +15 more