Hypoxia and Adipose Tissue Function and Dysfunction in Obesity
TLDR
Overall, hypoxia has pervasive effects on the function of adipocytes and appears to be a key factor in adipose tissue dysfunction in obesity.Abstract:
The rise in the incidence of obesity has led to a major interest in the biology of white adipose tissue. The tissue is a major endocrine and signaling organ, with adipocytes, the characteristic cel...read more
Citations
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The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
TL;DR: Detailed metabolic phenotyping of obese persons will be invaluable in understanding the pathophysiology of metabolic disturbances, and is needed to identify high-risk individuals or subgroups, thereby paving the way for optimization of prevention and treatment strategies to combat cardiometabolic diseases.
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What We Talk About When We Talk About Fat
TL;DR: New perspective is gained on the roles played by adipocyte in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues and how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
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Inflammatory mechanisms linking obesity and metabolic disease
TL;DR: Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.
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Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
TL;DR: NAFLD might be a more direct predictor of type 2 diabetes, cardiovascular disease, non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma than metabolic syndrome because it is associated with high liver fat content.
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Adapting to obesity with adipose tissue inflammation.
TL;DR: The connection between adipose tissue inflammation and the development of insulin resistance and catecholamine resistance is examined and the ensuing state of metabolic inflexibility is discussed.
References
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Obesity : Preventing and managing the global epidemic
D. S. Akram,Arne Astrup,T. Atinmo,J. L. Boissin,George A. Bray,K. Carroll,P. Chitson,C. Chunming,William H. Dietz,James O. Hill,Eric Jéquier,C. Komodiki,Yuji Matsuzawa,W. F. Mollentze,K. Moosa,M.I. Noor,K.S. Reddy,Jacob C. Seidell,V. Tanphaichitr,Ricardo Uauy,Paul Zimmet +20 more
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Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
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Prevalence of Overweight and Obesity in the United States, 1999-2004
Cynthia L. Ogden,Margaret D. Carroll,Lester R. Curtin,Margaret McDowell,Carolyn J. Tabak,Katherine M. Flegal +5 more
TL;DR: These estimates suggest that the increases in body weight are continuing in men and in children and adolescents while they may be leveling off in women; among women, no overall increases in the prevalence of obesity were observed.
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.