Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System
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TLDR
Evidence is presented that ependymal cells are neural stem cells and a novel process in the response to central nervous system injury is identified, identified in response to spinal cord injury.About:
This article is published in Cell.The article was published on 1999-01-08 and is currently open access. It has received 1948 citations till now. The article focuses on the topics: Neural stem cell & Ependymal Cell.read more
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Journal ArticleDOI
Mammalian neural stem cells.
TL;DR: Before the full potential of neural stem cells can be realized, the authors need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells.
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Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain
Fiona Doetsch,Isabelle Caillé,Daniel A. Lim,José Manuel García-Verdugo,Arturo Alvarez-Buylla +4 more
TL;DR: It is shown that SVZ astrocytes act as neural stem cells in both the normal and regenerating brain and give rise to cells that grow into multipotent neurospheres in vitro.
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Adult rat and human bone marrow stromal cells differentiate into neurons
TL;DR: Adult marrow stromal cells can be induced to overcome their mesenchymal commitment and may constitute an abundant and accessible cellular reservoir for the treatment of a variety of neurologic diseases.
Journal ArticleDOI
The glial nature of embryonic and adult neural stem cells
TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
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Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
Carla F. Kim,Erica L. Jackson,Amber Woolfenden,Sharon Lawrence,Imran Babar,Sinae Vogel,Denise Crowley,Roderick T. Bronson,Tyler Jacks +8 more
TL;DR: Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to bronchioalveolar stem cells as the putative cells of origin for this subtype of lung cancer.
References
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Journal ArticleDOI
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: Cells of the adult mouse striatum have the capacity to divide and differentiate into neurons and astrocytes.
Journal ArticleDOI
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Joseph Altman,Gopal D. Das +1 more
TL;DR: It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.
Journal ArticleDOI
CNS stem cells express a new class of intermediate filament protein.
TL;DR: The predicted amino acid sequence of the nestin gene product shows that nestin defines a distinct sixth class of intermediate filament protein, extending a model in which transitions in intermediate filament gene expression reflect major steps in the pathway of neural differentiation.
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Long-distance neuronal migration in the adult mammalian brain
TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.
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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain
TL;DR: The results suggest that chains of migrating neuroblasts in the SVZ may be derived from Type C cells, which had immature ultrastructural characteristics and were nestin-positive but negative to the other markers.
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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system
Brent A. Reynolds,Samuel Weiss +1 more