Immunological Functions of the Omentum
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TLDR
The omentum collects metastasizing tumor cells and supports tumor growth by immunological and metabolic mechanisms and is involved in peritoneal immunity.About:
This article is published in Trends in Immunology.The article was published on 2017-07-01 and is currently open access. It has received 188 citations till now. The article focuses on the topics: Immune system & Adipose tissue.read more
Citations
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Journal ArticleDOI
Genetic and environmental risk factors for rheumatoid arthritis
Kevin D. Deane,M. Kristen Demoruelle,Lindsay B. Kelmenson,Kristine A. Kuhn,Jill M. Norris,V. Michael Holers +5 more
TL;DR: A major challenge to the field will be to investigate the full spectrum of the development of RA, from initiation and propagation of autoimmunity during preclinical RA and transition to clinically apparent synovitis and classifiable RA, to determine which genetic and environmental factors are important at each stage of disease development.
OtherDOI
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Maggie S Burhans,Maggie S Burhans,Derek K. Hagman,Jessica N. Kuzma,Kelsey A Schmidt,Kelsey A Schmidt,Mario Kratz,Mario Kratz +7 more
TL;DR: Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues.
Journal ArticleDOI
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum
TL;DR: It is identified that neutrophil influx into the omentum is a prerequisite premetastatic step in orthotopic ovarian cancer models and raised the possibility that blockade of NET formation prevents omental metastasis.
Journal ArticleDOI
Adipose-tissue plasticity in health and disease
TL;DR: Adipose tissue is an extraordinarily flexible and heterogeneous organ as discussed by the authors , and it regulates many aspects of whole-body physiology, including food intake, maintenance of energy levels, insulin sensitivity, body temperature, and immune responses.
References
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Journal ArticleDOI
Ontogeny of milky spots in the human greater omentum: an immunochemical study
Lambert F. G. Krist,Hans Koenen,W. Calame,J.J. van der Harten,J.C. van der Linden,I.L. Eestermans,Sybren Meyer,R.H.J. Beelen +7 more
TL;DR: The development and the earliest forms of milky spots in the human greater omentum were studied, with special attention to the macrophage population.
Journal ArticleDOI
Vitamin A-dependent transcriptional activation of the nuclear factor of activated T cells c1 (NFATc1) is critical for the development and survival of B1 cells.
Mikako Maruya,Keiichiro Suzuki,Hanae Fujimoto,Michio Miyajima,Osami Kanagawa,Teruhiko Wakayama,Sidonia Fagarasan +6 more
TL;DR: It is demonstrated that injection of all-trans retinoic acid induces the expression of NFATc1, particularly from the constitutive P2 promoter, and leads to the increase of the B1 cells, which is critical for regulating NFAT c1 expression and for maintenance of the natural memory B cell compartment.
Journal ArticleDOI
Characterization of mouse mediastinal fat-associated lymphoid clusters.
TL;DR: It is suggested that the mouse genetic background affects LC size and number and clusters can be considered as niches for Th cell production in mouse mediastinal fat tissues.
Proceedings ArticleDOI
SP0035 Inflammation-induced formation of fat associated lymphoid clusters
TL;DR: Fat-associated lymphoid clusters have a dual role during immune responses at the initial stages of infection or inflammation and at later stages act as reservoirs of tissue resident memory T cells through their stromal cell expression of survival factors and their association with adipocytes to support Trm metabolism and survival
Journal Article
Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model
Sandra J. Yokota,John G. Facciponte,Raymond J. Kelleher,Leonard D. Shultz,Jenni L Loyall,Robert R. Parsons,Kunle Odunsi,John G. Frelinger,Edith M. Lord,Scott A. Gerber,Sathy V. Balu-Iyer,Richard B. Bankert +11 more
TL;DR: The omental tumor xenograft (OTX) model provides for the first time the opportunity to study in vivo the cellular and molecular events contributing to the arrest in T cell function in human ovarian tumors.