Immunological Functions of the Omentum
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TLDR
The omentum collects metastasizing tumor cells and supports tumor growth by immunological and metabolic mechanisms and is involved in peritoneal immunity.About:
This article is published in Trends in Immunology.The article was published on 2017-07-01 and is currently open access. It has received 188 citations till now. The article focuses on the topics: Immune system & Adipose tissue.read more
Citations
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Journal ArticleDOI
Genetic and environmental risk factors for rheumatoid arthritis
Kevin D. Deane,M. Kristen Demoruelle,Lindsay B. Kelmenson,Kristine A. Kuhn,Jill M. Norris,V. Michael Holers +5 more
TL;DR: A major challenge to the field will be to investigate the full spectrum of the development of RA, from initiation and propagation of autoimmunity during preclinical RA and transition to clinically apparent synovitis and classifiable RA, to determine which genetic and environmental factors are important at each stage of disease development.
OtherDOI
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Maggie S Burhans,Maggie S Burhans,Derek K. Hagman,Jessica N. Kuzma,Kelsey A Schmidt,Kelsey A Schmidt,Mario Kratz,Mario Kratz +7 more
TL;DR: Taken together, adipose tissue inflammation is a key factor in the development of insulin resistance and type 2 diabetes in obesity, along with other factors that likely include inflammation and fat accumulation in other metabolically active tissues.
Journal ArticleDOI
Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum
TL;DR: It is identified that neutrophil influx into the omentum is a prerequisite premetastatic step in orthotopic ovarian cancer models and raised the possibility that blockade of NET formation prevents omental metastasis.
Journal ArticleDOI
Adipose-tissue plasticity in health and disease
TL;DR: Adipose tissue is an extraordinarily flexible and heterogeneous organ as discussed by the authors , and it regulates many aspects of whole-body physiology, including food intake, maintenance of energy levels, insulin sensitivity, body temperature, and immune responses.
References
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Journal ArticleDOI
The greater omentum: Its applicability to cancer surgery and cancer therapy
Rhodri Williams,Harvey White +1 more
Journal ArticleDOI
Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity.
TL;DR: The role of secretory IgAs for regulation of microbial communities is summarized and clues as to how the gut microbiota contributes to the development of the gut‐associated lymphoid tissues are provided.
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Insufficient ability of omental milky spots to prevent peritoneal tumor outgrowth supports omentectomy in minimal residual disease.
Steven J. Oosterling,G.J. van der Bij,Marijn Bögels,J.R.M. van der Sijp,Robert H.J. Beelen,Sybren L. Meijer,M. van Egmond +6 more
TL;DR: Since the ability of omental milky spots is, even in MRD, insufficient to prevent intra abdominal tumor outgrowth, omentectomy, which reduces tumor load, is recommended in surgical treatment of intra abdominal tumors that are prone to disseminate intraperitoneally.
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Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots.
Simon Berberich,Sabrina Dähne,Angela Schippers,Thorsten Peters,Werner Müller,Elisabeth Kremmer,Reinhold Förster,Oliver Pabst +7 more
TL;DR: Analysis of mouse migratory processes reveals the existence of alternative routes for B2 cell entry into the peritoneal cavity and identifies integrins as key factors forperitoneal B2 Cell homeostasis, mediating B2cell migration into and out of the peritonal cavity as well as their retention at this site.
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Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.
Konrad Buscher,Huiyu Wang,Xueli Zhang,Paul Striewski,Benedikt Wirth,Gurpanna Saggu,Stefan Lütke-Enking,Tanya N. Mayadas,Klaus Ley,Lydia Sorokin,Jian Song +10 more
TL;DR: HEVs are identified as a clinically relevant vascular recruitment site for neutrophils in acute peritonitis that is indispensable for host defence against early systemic bacterial spread and sepsis.