Immunopathogenesis of osteoarthritis
Abdul Haseeb,Tariq M. Haqqi +1 more
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TLDR
There is considerable success in the treatment of rheumatoid arthritis using anti-cytokine therapies in OA, however, these therapies did not show much effect, highlighting more complex nature of pathogenesis of OA.About:
This article is published in Clinical Immunology.The article was published on 2013-03-01 and is currently open access. It has received 312 citations till now. The article focuses on the topics: Osteoarthritis & Acquired immune system.read more
Citations
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Journal ArticleDOI
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
William H. Robinson,Christin M. Lepus,Christin M. Lepus,Qian Wang,Qian Wang,Harini Raghu,Harini Raghu,Rong Mao,Rong Mao,Tamsin M. Lindstrom,Tamsin M. Lindstrom,Jeremy Sokolove,Jeremy Sokolove +12 more
TL;DR: Osteoarthritis has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis, and increasing insight into the inflammatory underpinnings of OA holds promise for the development of new, disease-modifying therapies.
Journal ArticleDOI
Intra-articular treatment options for knee osteoarthritis
TL;DR: Current and future intra-articular therapies for knee OA are critically appraise and generally positive efficacy conclusions concerning mesenchymal ‘stem’ cell therapy for knee cartilage pathology might be overstated owing to selective outcome reporting.
Journal ArticleDOI
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
TL;DR: The data indicates that Wogonin exerts chondroprotective effects through the suppression of molecular events involved in oxidative stress, inflammation and matrix degradation in OA chONDrocytes and cartilage explants.
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Inflammation-Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing "the Epidemic" of Chronic Diseases.
TL;DR: It is concluded that healthcare professionals must advocate for an anti-inflammatory lifestyle at the patient level as well as at the local and national levels to enhance population health and well-being.
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Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives.
C. Randall Harrell,Bojana Simovic Markovic,Crissy Fellabaum,Aleksandar Arsenijevic,Vladislav Volarevic +4 more
TL;DR: Current knowledge and future perspectives regarding molecular and cellular mechanisms responsible for beneficial effects of autologous and allogeneic MSCs in the treatment of OA are emphasized.
References
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Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
TL;DR: A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor and interleukin-6 but not interferon gamma (IFN-gamma).
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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
TL;DR: The current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA is discussed and the potential of anticytokine therapy in the treatment of this disease is addressed.
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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Christian Termeer,Frauke Benedix,Jonathon Sleeman,Christina Fieber,Ursula Voith,Thomas Ahrens,Kensuke Miyake,Marina A. Freudenberg,Christopher Galanos,Jan-Christoph Simon +9 more
TL;DR: This is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs.
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The role of chemokine receptors in primary, effector, and memory immune responses.
TL;DR: The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion.
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The role of synovitis in osteoarthritis pathogenesis
TL;DR: Most studies have concluded that the presence of synovitis in OA is associated with more severe pain and joint dysfunction, and may be predictive of faster rates of cartilage loss in certain patient populations.