Journal ArticleDOI
Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial
Joe Conaghan,A.A. Chen,S.P. Willman,K. Ivani,Philip E. Chenette,Robert Boostanfar,Valerie L. Baker,G. David Adamson,Mary E. Abusief,M. Gvakharia,Kevin E. Loewke,Shehua Shen +11 more
TLDR
Experienced embryologists using Eeva in combination with D3 morphology significantly improved their ability to identify embryos that would reach the usable blastocyst stage, and adjunctive use of morphology plus Eeva also reduced interindividual variability in embryo selection.About:
This article is published in Fertility and Sterility.The article was published on 2013-08-01. It has received 261 citations till now. The article focuses on the topics: Blastocyst Transfer.read more
Citations
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Journal ArticleDOI
Morphokinetic parameters of early embryo development via time lapse monitoring and their effect on embryo selection and ICSI outcomes: a prospective cohort study
Charalampos Siristatidis,Maria Aggeliki Komitopoulou,Andreas Makris,Afrodite Sialakouma,Mitrodora Botzaki,George Mastorakos,George Salamalekis,Stefano Bettocchi,Giles Anthony Palmer +8 more
TL;DR: Morphokinetic parameters of early embryo development via TLM are related to the characteristics of subfertile patients and associated with ICSI outcomes.
Journal ArticleDOI
Live births after embryo selection using morphokinetics versus conventional morphology: a retrospective analysis
Simon Fishel,Alison Campbell,Sue Montgomery,Rachel Smith,Lynne Nice,Samantha Duffy,L. Jenner,Kathyrn Berrisford,Louise Kellam,Robert A. Smith,Ivy D'Cruz,Ashley Beccles +11 more
TL;DR: This is the largest study of the prospective use of time-lapse imaging algorithms in IVF reporting on live birth outcome, although the nature of purely a closed system versus standard incubation could not be assessed.
Journal ArticleDOI
Time-lapse imaging algorithms rank human preimplantation embryos according to the probability of live birth.
Simon Fishel,Alison Campbell,Sue Montgomery,Rachel Smith,Lynne Nice,Samantha Duffy,L. Jenner,Kathryn Berrisford,Louise Kellam,Robert A. Smith,Fiona Foad,Ashley Beccles +11 more
TL;DR: Time-lapse imaging morphokinetic-based algorithms for blastocysts can provide objective hierarchical ranking of embryos for predicting live birth and may have greater discriminating power than conventional blastocyst morphology assessment.
Journal ArticleDOI
A pilot randomized controlled trial of Day 3 single embryo transfer with adjunctive time-lapse selection versus Day 5 single embryo transfer with or without adjunctive time-lapse selection
Daniel J. Kaser,Charles L. Bormann,Stacey A. Missmer,Stacey A. Missmer,Leslie V. Farland,Leslie V. Farland,Elizabeth S. Ginsburg,Catherine Racowsky +7 more
TL;DR: The evidence is insufficient to conclude that adjunctive use of the Eeva™ test on D3 or D5 improves CPR per transfer as compared to D5 selection with conventional morphology, and the findings do not support the clinical application of these time-lapse markers.
Journal ArticleDOI
Using the Eeva Test™ adjunctively to traditional day 3 morphology is informative for consistent embryo assessment within a panel of embryologists with diverse experience
Michael P. Diamond,Vaishali Suraj,Erica J. Behnke,Xinli Yang,Marlane Angle,Jaclyn C. Lambe-Steinmiller,Rachel Watterson,Kelly Athayde Wirka,A.A. Chen,Shehua Shen +9 more
TL;DR: The Eeva Test, an automated, time-lapse enabled prognostic test, used adjunctively with morphology, is informative in helping embryologists with various levels of experience select embryos with high developmental potential.
References
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Journal ArticleDOI
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
TL;DR: The ability to transfer one high-scoring blastocyst should lead to pregnancy rates greater than 60%, without the complication of twins, according to a retrospective review of blastocysts transfer in an IVF clinic.
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The use of morphokinetics as a predictor of embryo implantation
TL;DR: A multivariable model is proposed based on the findings to classify embryos according to their probability of implantation and it is proposed that the image acquisition and time-lapse analysis system makes it possible to determine exact timing of embryo cleavages in a clinical setting.
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Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
Wong Connie C,Kevin E. Loewke,Nancy L. Bossert,Barry Behr,Christopher J. De Jonge,Thomas M. Baer,Renee A. Reijo Pera +6 more
TL;DR: It is found that success in progression to the blastocyst stage can be predicted with >93% sensitivity and specificity by measuring three dynamic, noninvasive imaging parameters by day 2 after fertilization, before embryonic genome activation (EGA).
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Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography.
TL;DR: Time-lapse video cinematography is shown to be an excellent tool for studying fertilization and early embryo development, and it was found that good quality embryos arose from oocytes that had more uniform timing from injection to pronuclear abuttal and tended to have a longer cytoplasmic wave.
Journal ArticleDOI
Epigenetics and assisted reproductive technology: a call for investigation.
TL;DR: The need for investigation of two major questions is highlighted: large-scale case-control studies of ART outcomes, including long-term assessment of the incidence of birth defects and cancer, and investigation of the relationship between epigenetic errors in both offspring and parents.