Journal ArticleDOI
Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial
Joe Conaghan,A.A. Chen,S.P. Willman,K. Ivani,Philip E. Chenette,Robert Boostanfar,Valerie L. Baker,G. David Adamson,Mary E. Abusief,M. Gvakharia,Kevin E. Loewke,Shehua Shen +11 more
TLDR
Experienced embryologists using Eeva in combination with D3 morphology significantly improved their ability to identify embryos that would reach the usable blastocyst stage, and adjunctive use of morphology plus Eeva also reduced interindividual variability in embryo selection.About:
This article is published in Fertility and Sterility.The article was published on 2013-08-01. It has received 261 citations till now. The article focuses on the topics: Blastocyst Transfer.read more
Citations
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Journal ArticleDOI
Dynamics of cytoplasm and cleavage divisions correlates with preimplantation embryo development.
TL;DR: It is shown for the first time that parameters describing cytoplasmic dynamics and cleavage divisions independently correspond to mouse embryo's capacity to form a high-quality blastocyst.
Journal ArticleDOI
Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study
Linda Sundvall,Linda Sundvall,Kirstine Kirkegaard,Kirstine Kirkegaard,Hans Jakob Ingerslev,Hans Jakob Ingerslev,Ulla Breth Knudsen,Ulla Breth Knudsen +7 more
TL;DR: The findings suggest that the causative factor for subfertility in PCOS is not related to timing of development in the pre-implantation embryo.
Journal ArticleDOI
Time-lapse technology for embryo culture and selection
Kersti Lundin,Hannah Park +1 more
TL;DR: New methodology, involving machine learning, where every image from the time-lapse documentation is analysed by a computer programme, looking for patterns that link to outcome, may in the future provide a more accurate and non-biased embryo selection.
Journal ArticleDOI
Combined effects of individual culture and atmospheric oxygen on preimplantation mouse embryos in vitro.
TL;DR: Combining individual culture and 20% oxygen is detrimental to embryo development, as shown in mice cultured under physiological or atmospheric oxygen.
Posted Content
Robust and generalizable embryo selection based on artificial intelligence and time-lapse image sequences.
TL;DR: In this article, the authors investigated how a deep learning-based embryo selection model using only time-lapse image sequences performs across different patient ages and clinical conditions, and how it correlates with traditional morphokinetic parameters.
References
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Journal ArticleDOI
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
TL;DR: The ability to transfer one high-scoring blastocyst should lead to pregnancy rates greater than 60%, without the complication of twins, according to a retrospective review of blastocysts transfer in an IVF clinic.
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The use of morphokinetics as a predictor of embryo implantation
TL;DR: A multivariable model is proposed based on the findings to classify embryos according to their probability of implantation and it is proposed that the image acquisition and time-lapse analysis system makes it possible to determine exact timing of embryo cleavages in a clinical setting.
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Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
Wong Connie C,Kevin E. Loewke,Nancy L. Bossert,Barry Behr,Christopher J. De Jonge,Thomas M. Baer,Renee A. Reijo Pera +6 more
TL;DR: It is found that success in progression to the blastocyst stage can be predicted with >93% sensitivity and specificity by measuring three dynamic, noninvasive imaging parameters by day 2 after fertilization, before embryonic genome activation (EGA).
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Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography.
TL;DR: Time-lapse video cinematography is shown to be an excellent tool for studying fertilization and early embryo development, and it was found that good quality embryos arose from oocytes that had more uniform timing from injection to pronuclear abuttal and tended to have a longer cytoplasmic wave.
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Epigenetics and assisted reproductive technology: a call for investigation.
TL;DR: The need for investigation of two major questions is highlighted: large-scale case-control studies of ART outcomes, including long-term assessment of the incidence of birth defects and cancer, and investigation of the relationship between epigenetic errors in both offspring and parents.