Journal ArticleDOI
Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial
Joe Conaghan,A.A. Chen,S.P. Willman,K. Ivani,Philip E. Chenette,Robert Boostanfar,Valerie L. Baker,G. David Adamson,Mary E. Abusief,M. Gvakharia,Kevin E. Loewke,Shehua Shen +11 more
TLDR
Experienced embryologists using Eeva in combination with D3 morphology significantly improved their ability to identify embryos that would reach the usable blastocyst stage, and adjunctive use of morphology plus Eeva also reduced interindividual variability in embryo selection.About:
This article is published in Fertility and Sterility.The article was published on 2013-08-01. It has received 261 citations till now. The article focuses on the topics: Blastocyst Transfer.read more
Citations
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Journal ArticleDOI
Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope
TL;DR: The strategy of culturing and selecting embryos in the integrated EmbryoScope time-lapse monitoring system improves reproductive outcomes.
Journal ArticleDOI
Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization.
Pegah Khosravi,Ehsan Kazemi,Qiansheng Zhan,Jonas Malmsten,M. Toschi,Pantelis Zisimopoulos,Alexandros Sigaras,Stuart Lavery,Lee Cooper,Cristina Hickman,Marcos Meseguer,Zev Rosenwaks,Olivier Elemento,Nikica Zaninovic,Iman Hajirasouliha +14 more
TL;DR: An AI-driven approach provides a reproducible way to assess embryo quality and uncovers new, potentially personalized strategies to select embryos.
Journal ArticleDOI
Time-lapse systems for embryo incubation and assessment in assisted reproduction.
TL;DR: The potential advantages of a TLS include the ability to maintain a stable culture environment, therefore limiting the exposure of embryos to changes in gas composition, temperature and movement, and improving embryo selection for ART treatment by utilising additional information gained through monitoring embryo development.
Journal ArticleDOI
Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer
TL;DR: A retrospective analysis demonstrating that the deep learning model has a high level of predictability of the likelihood that an embryo will implant and may improve the effectiveness of previous approaches used for time-lapse imaging in embryo selection.
Journal ArticleDOI
Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3
TL;DR: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential.
References
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Journal ArticleDOI
The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysis
TL;DR: Elective-SET of embryos at the cleavage stage reduces the likelihood of live birth by 38% and multiple birth by 94%.
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A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator
Kirstine Kirkegaard,J. Hindkjær,Marie Louise Grøndahl,Ulrik Schiøler Kesmodel,Hans Jakob Ingerslev +4 more
TL;DR: Culture in the time-lapse incubator supports embryonic development equally to a conventional incubator and no differences in clinical pregnancy rate or implantation rate are found.
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Selection of high-potential embryos by culture in poly(dimethylsiloxane) microwells and time-lapse imaging
TL;DR: Individual embryos with the potential to develop to high-scoring blastocysts could be selected at 2-3 days of culture using this system by examining the times required to complete the second and third mitotic divisions.
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Blastocyst culture after repeated failure of cleavage-stage embryo transfers: a comparison of day 5 and day 6 transfers.
G. Barrenetxea,Arantza Lopez de Larruzea,Teresa Ganzabal,Rosario Jiménez,Koldo Carbonero,Miren Mandiola +5 more
TL;DR: Blastocyst transfer (preferably on day 5 after retrieval) appears to be a successful and improved alternative for patients with multiple failed IVF attempts and there should be a reduction in multiple pregnancy risk, because fewer embryos have to be transferred.
Journal ArticleDOI
Biomarkers identified with time-lapse imaging: discovery, validation, and practical application
TL;DR: Noninvasive biomarkers defined by time-lapse imaging studies that are based on a foundation of basic research, validated through prospective clinical studies, and enabled by a reliable quantification technology may improve IVF success rates, encourage broader adoption of single-embryo transfer, and reduce the risks associated with multiple gestation pregnancies.