Journal ArticleDOI
Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial
Joe Conaghan,A.A. Chen,S.P. Willman,K. Ivani,Philip E. Chenette,Robert Boostanfar,Valerie L. Baker,G. David Adamson,Mary E. Abusief,M. Gvakharia,Kevin E. Loewke,Shehua Shen +11 more
TLDR
Experienced embryologists using Eeva in combination with D3 morphology significantly improved their ability to identify embryos that would reach the usable blastocyst stage, and adjunctive use of morphology plus Eeva also reduced interindividual variability in embryo selection.About:
This article is published in Fertility and Sterility.The article was published on 2013-08-01. It has received 261 citations till now. The article focuses on the topics: Blastocyst Transfer.read more
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Dissertation
Analysis of early bovine embryogenesis after in vitro and in vivo oocyte maturation by time-lapse imaging and 3-D confocal microscopy
TL;DR: Time-lapse imaging of early embryonic cleavage was found to be a helpful and non-invasive tool to predict the developmental capacity of embryos and select embryos of good quality and 3-D images of embryos showed that fertilization with more than one sperm was a main cause for abnormal cleavage.
Journal ArticleDOI
Reply: Time-lapse parameters could not predict pregnancy: a hasty conclusion?
Kirstine Kirkegaard,Kirstine Kirkegaard,Ulrik Schiøler Kesmodel,Ulrik Schiøler Kesmodel,J. Hindkjær,Hans Jakob Ingerslev,Hans Jakob Ingerslev +6 more
Journal ArticleDOI
Time-lapse monitoring technologies for the selection of bovine in vitro fertilized embryos with high implantation potential
TL;DR: In this paper , a review of the potential application of TLM technology to improve fertility of bovine IVF embryos is presented, focusing on the results of human and Bovine TLM studies that can be applied to select embryos with high implantation potential.
Improving embryo quality in assisted reproduction
TL;DR: An intriguing feature of the human preimplantation embryo is investigated, i.e. its mosaic nature, and the occurrence of mitotic aneuploidies, to improve embryo quality in assisted reproductive technologies and to elucidate the effect of culture media on human preIMplantation embryos development and on the success rates of IVF/ICSI treatment.
Journal ArticleDOI
Limitações e controvérsias na determinação do valor preditivo de critérios de morfologia oocitária e embrionária
TL;DR: The optimization of embryo selection represents a large potential to increase treatment success rates, allowing the transfer of a reduced number of embryos and inimizing the risks of multiple pregnancy.
References
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Journal ArticleDOI
Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer
TL;DR: The ability to transfer one high-scoring blastocyst should lead to pregnancy rates greater than 60%, without the complication of twins, according to a retrospective review of blastocysts transfer in an IVF clinic.
Journal ArticleDOI
The use of morphokinetics as a predictor of embryo implantation
TL;DR: A multivariable model is proposed based on the findings to classify embryos according to their probability of implantation and it is proposed that the image acquisition and time-lapse analysis system makes it possible to determine exact timing of embryo cleavages in a clinical setting.
Journal ArticleDOI
Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
Wong Connie C,Kevin E. Loewke,Nancy L. Bossert,Barry Behr,Christopher J. De Jonge,Thomas M. Baer,Renee A. Reijo Pera +6 more
TL;DR: It is found that success in progression to the blastocyst stage can be predicted with >93% sensitivity and specificity by measuring three dynamic, noninvasive imaging parameters by day 2 after fertilization, before embryonic genome activation (EGA).
Journal ArticleDOI
Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography.
TL;DR: Time-lapse video cinematography is shown to be an excellent tool for studying fertilization and early embryo development, and it was found that good quality embryos arose from oocytes that had more uniform timing from injection to pronuclear abuttal and tended to have a longer cytoplasmic wave.
Journal ArticleDOI
Epigenetics and assisted reproductive technology: a call for investigation.
TL;DR: The need for investigation of two major questions is highlighted: large-scale case-control studies of ART outcomes, including long-term assessment of the incidence of birth defects and cancer, and investigation of the relationship between epigenetic errors in both offspring and parents.