In situ fabrication of metal-organic framework derived hybrid nanozymes for enhanced nanozyme-photothermal therapy of bacteria-infected wounds
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TLDR
In this paper, a metal-organic framework (MOF)-derived hybrid nanozymes antibacterial strategy for enhanced nanozyme-photothermal therapy (NPT) was proposed, which can not only prevent the aggregation of platinum nano-zymes and effectively reduce the mass transfer resistance during the kinetic reaction, but also inhibit the photoelectron-hole recombination in the process of photothermal therapy.Abstract:
In recent years, nanozyme-photothermal therapy (NPT) has attracted enormous interests owing to their enhanced therapeutic effects and less adverse effects in the treatment of infectious diseases. However, the development of nanozyme-photothermal agents (NPAs) that can rapidly, efficiently and synergistically combating pathogenic bacteria remains a huge challenge due to the limitation of size effect. Herein, by decorating platinum nanozymes on Zn-based photosensitizer, we report a novel metal-organic framework (MOF)-derived hybrid nanozymes antibacterial strategy for enhanced NPT. This strategy can not only prevent the aggregation of platinum nanozymes and effectively reduce the mass transfer resistance during the kinetic reaction, but also inhibit the photoelectron-hole recombination in the process of photothermal therapy (PTT) and improve the photothermal conversion performance. In the presence of a low concentration of hydrogen peroxide (H2O2), the superior nanocatalytic activity of the MOF-derived hybrid nanozymes can effectively catalyze the release of H2O2 to generate toxic hydroxyl radical (•OH), resulting in the increase of bacterial membrane permeability and thermal sensitivity. Once the near-infrared laser is introduced, the nanozyme-photothermal antibacterial platform can play the role of “nanoknife” to further induce the death of the damaged bacteria by physical cutting. In vitro and vivo in antibacterial assays confirm that the MOF-derived hybrid nanozymes have excellent antibacterial properties, which can serve as an antibacterial candidate with negligible adverse effect. Therefore, this work will open a new avenue for MOF-derived hybrid nanozymes in biomedical application.read more
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TL;DR: This review summarizes recent developments of MOF-enzyme composites with special emphasis on preparative techniques and the synergistic effects of enzymes and MOFs.
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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing
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Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
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Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy.
Yan Zhang,Faming Wang,Chaoqun Liu,Zhenzhen Wang,Lihua Kang,Yanyan Huang,Kai Dong,Jinsong Ren,Xiaogang Qu +8 more
TL;DR: By decorating platinum nanozymes on photosensitizer integrated MOFs, this work reports a simple yet versatile strategy for enhanced PDT that can facilitate the formation of 1O2 in hypoxic tumor site via H2O2-activated evolvement of O2, which can cause more serious damage to cancer cells.