In Vivo Assessment of Trabecular Bone Microarchitecture by High-Resolution Peripheral Quantitative Computed Tomography."
TLDR
HR-pQCT appears promising to assess bone density and microarchitecture at peripheral sites in terms of reproducibility and ability to detect age- and disease-related changes.Abstract:
Context: Assessment of trabecular microarchitecture may enhance the prediction of fracture risk and improve monitoring of treatment response. A new high-resolution peripheral quantitative computed tomography (HR-pQCT) system permits in vivo assessment of trabecular architecture and volumetric bone mineral density (BMD) at the distal radius and tibia with a voxel size of 82 μm3. Objective and Patients: We determined the short-term reproducibility of this device by measuring 15 healthy volunteers three times each. We compared HR-pQCT measurements in 108 healthy premenopausal, 113 postmenopausal osteopenic, and 35 postmenopausal osteoporotic women. Furthermore, we compared values in postmenopausal osteopenic women with (n = 35) and without previous fracture history (n = 78). Design and Setting: We conducted a cross-sectional study in a private clinical research center. Intervention and Main Outcome Measure: We took HR-pQCT measurements of the radius and tibia. Femoral neck and spine BMD were measured in post...read more
Citations
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Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
Ego Seeman,Pierre D. Delmas +1 more
TL;DR: In this article, a review discusses advances in knowledge regarding the composition and structure of bone, the modeling and remodeling of bone and the formation of bone during growth and its reconstruction in adults.
Journal ArticleDOI
Trabecular bone score: a noninvasive analytical method based upon the DXA image.
Barbara C. Silva,William D. Leslie,Heinrich Resch,Olivier Lamy,Olga Lesnyak,Neil Binkley,Eugene V. McCloskey,John A. Kanis,John P. Bilezikian +8 more
TL;DR: The trabecular bone score (TBS) as discussed by the authors is a gray-level textural metric that can be extracted from the two-dimensional lumbar spine dual-energy X-ray absorptiometry (DXA) image.
Journal ArticleDOI
Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis
TL;DR: The dual threshold method offers a robust and fully-automated alternative to the gold standard that can efficiently segment bone regions with accurate and repeatable results.
Journal ArticleDOI
Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study.
TL;DR: Combining the TBS trabecular texture index with BMD incrementally improves fracture prediction in postmenopausal women.
Journal ArticleDOI
Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions.
Klaus Engelke,Judith E. Adams,Gabriele Armbrecht,Peter Augat,Cesar E. Bogado,Mary L. Bouxsein,Dieter Felsenberg,Masako Ito,Sven Prevrhal,Didier Hans,E. Michael Lewiecki +10 more
TL;DR: The ISCD Official Positions for quantitative computed tomography (QCT) and peripheral QCT (pQCT), with supporting medical evidence, rationale, controversy, and suggestions for further study are presented.
References
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