Journal ArticleDOI
Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria.
TLDR
Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.Abstract:
The influence of intestinal worm infections on malaria was studied in individuals from Dielmo, Senegal in 1998. Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.read more
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Immunomodulation by phosphocholine—Biosynthesis, structures and immunological implications of parasitic PC-epitopes
Julia Grabitzki,Günter Lochnit +1 more
TL;DR: The implication of parasite-specific transferases in the biosynthesis of the PC-epitopes and the sensitivity of parasites towards disruption of the choline metabolism offers new perspectives for the development of anti-parasitic drugs and therapies.
Journal ArticleDOI
Plasmodium falciparum and soil-transmitted helminth co-infections among children in sub-Saharan Africa: a systematic review and meta-analysis
Abraham Degarege,Emir Veledar,Dawit Degarege,Berhanu Erko,Mathieu Nacher,Purnima Madhivanan,Purnima Madhivanan +6 more
TL;DR: The findings suggest that STH infection may increase susceptibility to asymptomatic/uncomplicated P. falciparum infection but may protect malaria-related anaemia in children.
Journal ArticleDOI
Schistosoma haematobium effects on Plasmodium falciparum infection modified by soil-transmitted helminths in school-age children living in rural areas of Gabon.
Jean Claude Dejon-Agobé,Jeannot Fréjus Zinsou,Yabo Josiane Honkpehedji,Ulysse Ateba-Ngoa,Jean-Ronald Edoa,Bayode Romeo Adegbite,Ghyslain Mombo-Ngoma,Selidji T Agnandji,Michael Ramharter,Peter G. Kremsner,Bertrand Lell,Martin P. Grobusch,Martin P. Grobusch,Ayola A. Adegnika,Ayola A. Adegnika +14 more
TL;DR: The results showed that schistosomiasis in children tends to increase the risk of plasmodium infection but a combined effect with Trichuris trichiura or hookworm infection clearly increases the risk.
Journal ArticleDOI
Worms and malaria: blind men feeling the elephant?
TL;DR: Observational studies in Thailand have shown that although P. falciparum malaria incidence increased two-fold in helminth-infected patients, there was a 64% reduction of cerebral malaria and an 84% reduce of acute renal failure in helmineth- Infected patients relative to those without helminths.
Journal ArticleDOI
Associations between Peripheral Plasmodium falciparum Malaria Parasitemia, Human Immunodeficiency Virus, and Concurrent Helminthic Infection among Pregnant Women in Malawi
Michael C. Thigpen,Scott J Filler,Peter N. Kazembe,Monica E. Parise,Allan Macheso,Carl H. Campbell,Robert D. Newman,Richard W. Steketee,Mary J. Hamel +8 more
TL;DR: Conurrent helminthic infection had both positive and negative effects on malaria parasitemia among pregnant women in Malawi, and HIV and hookworm infection were independently associated with malaria infection.
References
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Journal ArticleDOI
The dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of senegal
Jean-François Trape,Christophe Rogier,Lassana Konate,Nafissatou Diagne,Hilaire Bouganali,Bruno Canque,Fabrice Legros,Assane Badji,Gora Ndiaye,Papa Ndiaye,Karima Brahimi,Ousmane Faye,Pierre Druilhe,Luiz Pereira da Silva +13 more
TL;DR: The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
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Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity.
TL;DR: The hypothesis that nonprotected subjects have antibodies to epitopes critical for protection, but that these antibodies are nonfunctional is formed, bringing some clues to the very long delay required to reach protection against malaria and clearly stress the need to investigate immune responses in both quantitative and qualitative terms.
Journal ArticleDOI
Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations.
TL;DR: Evidence is provided for an age-dependent threshold effect of parasitemia that allows parasite density to be used to distinguish malaria attacks from other causes of fever within an individual and should facilitate the accurate evaluation of the incidence of clinical malaria in highly endemic areas.