Journal ArticleDOI
Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria.
TLDR
Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.Abstract:
The influence of intestinal worm infections on malaria was studied in individuals from Dielmo, Senegal in 1998. Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.read more
Citations
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Journal ArticleDOI
Correlation between malaria incidence and prevalence of soil-transmitted helminths in Colombia: An ecologic evaluation
Carlos Andrés Valencia,Julián Alfredo Fernández,Zulma M. Cucunubá,Patricia Reyes,Myriam Consuelo López,Sofía Duque +5 more
TL;DR: This work showed an ecologic correlation in Colombia between malaria incidence and soil-transmitted helminths prevalence, which could suggest that either there is an association between these two groups of parasites, or could be explained by the presence of common structural determinants for both diseases.
Book ChapterDOI
Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases?
TL;DR: Patients affected with Crohn’s disease or ulcerative colitis were treated with the ova of a porcine whipworm Trichuris suis, which resulted in clinical amelioration of both diseases, which would suggest the possible use of this protein in the treatment of Th2-mediated disorders, such as allergic diseases.
Journal ArticleDOI
The Best of All Worlds: Streptococcus pneumoniae Conjunctivitis through the Lens of Community Ecology and Microbial Biogeography.
Lawson Ung,Paulo J.M. Bispo,Noelle C. Bryan,Noelle C. Bryan,Camille André,James Chodosh,Michael S. Gilmore +6 more
TL;DR: It is highlighted how a unified model of microbial biogeography, one which incorporates the classic ecological principles of selection, diversification, dispersion and ecological drift, can be used to explain community dynamics in the settings of both health and disease.
Journal ArticleDOI
Maladjusted host immune responses induce experimental cerebral malaria-like pathology in a murine Borrelia and Plasmodium co-infection model.
Johan Normark,Maria Nelson,Patrik Engström,Marie Andersson,Rafael Björk,Thomas Moritz,Anna Fahlgren,Sven Bergström +7 more
TL;DR: This study shows that a situation mimicking experimental cerebral malaria (ECM) is induced in co-infected mice due to loss of timing and control over regulatory mechanisms in antigen presenting cells.
References
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Journal ArticleDOI
The dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of senegal
Jean-François Trape,Christophe Rogier,Lassana Konate,Nafissatou Diagne,Hilaire Bouganali,Bruno Canque,Fabrice Legros,Assane Badji,Gora Ndiaye,Papa Ndiaye,Karima Brahimi,Ousmane Faye,Pierre Druilhe,Luiz Pereira da Silva +13 more
TL;DR: The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
Journal ArticleDOI
Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity.
TL;DR: The hypothesis that nonprotected subjects have antibodies to epitopes critical for protection, but that these antibodies are nonfunctional is formed, bringing some clues to the very long delay required to reach protection against malaria and clearly stress the need to investigate immune responses in both quantitative and qualitative terms.
Journal ArticleDOI
Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations.
TL;DR: Evidence is provided for an age-dependent threshold effect of parasitemia that allows parasite density to be used to distinguish malaria attacks from other causes of fever within an individual and should facilitate the accurate evaluation of the incidence of clinical malaria in highly endemic areas.