Journal ArticleDOI
Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria.
TLDR
Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.Abstract:
The influence of intestinal worm infections on malaria was studied in individuals from Dielmo, Senegal in 1998. Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.read more
Citations
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The Effect of Intestinal Parasitic Infection on the Clinical Outcome of Malaria in Coinfected Children in Cameroon.
TL;DR: IPI was not observed to be associated with the severity of malaria, the malaria parasite density, and the haemoglobin concentration in coinfected children in Cameroon, suggesting that the clinical outcome of malaria in children coinfecting with intestinal parasites may depend on the geographical setting after all.
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Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice
TL;DR: Conurrent malaria infection also suppressed helminth-associated IL-4 responses, indicating that immunologic counter-regulation occurs during co-infection with malaria and intestinal helminths.
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Immune responses during helminth-malaria co-infection: a pilot study in Ghanaian school children.
TL;DR: A pilot study is described in Ghanaian school children where anti-malarial responses in children living in an urban area, where the prevalence of helminth and Plasmodium falciparum infections was low, are compared with that of childrenliving in a rural area with high prevalence ofHelminthand malaria co-infection.
Journal ArticleDOI
Distribution and Risk Factors for Plasmodium and Helminth Co-infections: A Cross-Sectional Survey among Children in Bagamoyo District, Coastal Region of Tanzania
Nahya Salim,Stefanie Knopp,Omar Lweno,Ummi Abdul,Ali Mohamed,Tobias Schindler,Julian Rothen,John Masimba,Denis Kwaba,Alisa S. Mohammed,Fabrice Althaus,Salim Abdulla,Marcel Tanner,Claudia Daubenberger,Blaise Genton +14 more
TL;DR: It is suggested that STH and Plasmodium infections tend to occur in the same children, with increasing prevalence of co-infection with age, and calls for an integrated approach such as using mass chemotherapy with dual effect coupled with improved housing, sanitation and hygiene for the control of both parasitic infections.
Journal ArticleDOI
Co-endemicity of Plasmodium falciparum and Intestinal Helminths Infection in School Age Children in Rural Communities of Kwara State Nigeria
Ayodele Adedoja,Bukola Deborah Tijani,Ajibola A. Akanbi,Taiwo Adetola Ojurongbe,Oluwaseyi A. Adeyeba,Olusola Ojurongbe +5 more
TL;DR: It is suggested that multiple parasitic infections are common in school age children in rural communities of Kwara State Nigeria and the Hymenolepis spp.
References
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Journal ArticleDOI
The dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of senegal
Jean-François Trape,Christophe Rogier,Lassana Konate,Nafissatou Diagne,Hilaire Bouganali,Bruno Canque,Fabrice Legros,Assane Badji,Gora Ndiaye,Papa Ndiaye,Karima Brahimi,Ousmane Faye,Pierre Druilhe,Luiz Pereira da Silva +13 more
TL;DR: The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
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Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity.
TL;DR: The hypothesis that nonprotected subjects have antibodies to epitopes critical for protection, but that these antibodies are nonfunctional is formed, bringing some clues to the very long delay required to reach protection against malaria and clearly stress the need to investigate immune responses in both quantitative and qualitative terms.
Journal ArticleDOI
Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations.
TL;DR: Evidence is provided for an age-dependent threshold effect of parasitemia that allows parasite density to be used to distinguish malaria attacks from other causes of fever within an individual and should facilitate the accurate evaluation of the incidence of clinical malaria in highly endemic areas.