Journal ArticleDOI
Increased frequency of malaria attacks in subjects co-infected by intestinal worms and Plasmodium falciparum malaria.
TLDR
Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.Abstract:
The influence of intestinal worm infections on malaria was studied in individuals from Dielmo, Senegal in 1998. Results suggest that, compared with those infected, individuals free of helminths had the same degree of protection against malaria as that provided by sickle-cell trait, the most potent factor of resistance to malaria identified to date.read more
Citations
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Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency
TL;DR: It was found that coinfected mice, particularly those that did not have microfilaremia, had more severe anemia and loss of body mass than did mice with malaria alone, and this was associated with increased interferon- gamma responsiveness.
Journal ArticleDOI
Association of schistosoma haematobium infection with protection against acute plasmodium falciparum malaria in malian children
Kirsten E. Lyke,Alassane Dicko,Abdoulaye Dabo,Lansana Sangaré,Abdoulaye K. Kone,Drissa Coulibaly,Ando B. Guindo,Karim Traore,Modibo Daou,Issa Diarra,Marcelo B. Sztein,Christopher V. Plowe,Ogobara K. Doumbo +12 more
TL;DR: It is concluded that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner.
Journal ArticleDOI
Do antenatal parasite infections devalue childhood vaccination
A. Desiree LaBeaud,A. Desiree LaBeaud,Indu Malhotra,Maria J. King,Christopher L. King,Charles H. King +5 more
TL;DR: A review of efficacy and effectiveness studies of vaccination among individuals with chronic parasitic infections was conducted, using PUBMED database searches and analysis of data from the authors' published and unpublished studies to suggest that antiparasite therapy can improve the effectiveness of several human vaccines.
Journal ArticleDOI
The Synergistic Effect of Concomitant Schistosomiasis, Hookworm, and Trichuris Infections on Children's Anemia Burden
Amara E. Ezeamama,Amara E. Ezeamama,Stephen T. McGarvey,Luz P. Acosta,Sally Zierler,Daria L. Manalo,Hai-Wei Wu,Jonathan D. Kurtis,Jonathan D. Kurtis,Vincent Mor,Remigio M. Olveda,Jennifer F. Friedman,Jennifer F. Friedman +12 more
TL;DR: Co-infections of hookworm and either S. japonicum or T. trichiura were associated with higher levels of anemia than would be expected if the effects of these species had only independent effects on anemia, suggesting that integrated anti-helminthic treatment programs with simultaneous deworming for S.Japonicum and some geohelminths could yield a greater than additive benefit for reducing anemia in helminth-endemic regions.
Journal ArticleDOI
Major Burden of Severe Anemia from Non-Falciparum Malaria Species in Southern Papua: A Hospital-Based Surveillance Study
Nicholas M. Douglas,Daniel A. Lampah,Enny Kenangalem,Julie A. Simpson,Jeanne Rini Poespoprodjo,Paulus Sugiarto,Nicholas M. Anstey,Ric N. Price +7 more
TL;DR: Hospital-based surveillance data is used to estimate the risk of severe anemia and mortality associated with endemic Plasmodium species in southern Papua, Indonesia.
References
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Journal ArticleDOI
The dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of senegal
Jean-François Trape,Christophe Rogier,Lassana Konate,Nafissatou Diagne,Hilaire Bouganali,Bruno Canque,Fabrice Legros,Assane Badji,Gora Ndiaye,Papa Ndiaye,Karima Brahimi,Ousmane Faye,Pierre Druilhe,Luiz Pereira da Silva +13 more
TL;DR: The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
Journal ArticleDOI
Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity.
TL;DR: The hypothesis that nonprotected subjects have antibodies to epitopes critical for protection, but that these antibodies are nonfunctional is formed, bringing some clues to the very long delay required to reach protection against malaria and clearly stress the need to investigate immune responses in both quantitative and qualitative terms.
Journal ArticleDOI
Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations.
TL;DR: Evidence is provided for an age-dependent threshold effect of parasitemia that allows parasite density to be used to distinguish malaria attacks from other causes of fever within an individual and should facilitate the accurate evaluation of the incidence of clinical malaria in highly endemic areas.