Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond.
Vasiliki Michopoulos,Vasiliki Michopoulos,Abigail Powers,Charles F. Gillespie,Kerry J. Ressler,Tanja Jovanovic +5 more
TLDR
The available data suggest that targeting inflammation may serve as a potential therapeutic target for treating fear- and anxiety-based disorders in the future, but the field must continue to characterize the specific role pro-inflammatory signaling in the maintenance of these unique psychiatric conditions.About:
This article is published in Neuropsychopharmacology.The article was published on 2017-01-01 and is currently open access. It has received 425 citations till now. The article focuses on the topics: Phobias & Fear-potentiated startle.read more
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Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
TL;DR: Neuroimaging effects of inflammation on reward and threat circuitry may be used as biomarkers of inflammation for future development of novel therapeutic strategies to better treat mood and anxiety-related disorders in patients with high inflammation.
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Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation
TL;DR: A narrative review of relevant evidence from mainly human research on the ten most acknowledged neurobiological allostatic pathways exerting enduring adverse effects of ELS even decades later shows most findings back a causal relation between ELS and psychobiological maladjustment in later life.
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Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses.
TL;DR: A cross-disorder study by systematically evaluating the meta-analysis results of inflammation-related factors in eight major psychiatric disorders, showing that well-powered case–control studies provided more consistent results than underpowered studies when one factor was meta-analysed by different researchers.
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Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder.
TL;DR: It is proposed that a state of endocannabinoid deficiency could represent a stress susceptibility endophenotype predisposing to the development of trauma- related psychopathology and provide biologically plausible support for the self-medication hypotheses used to explain high rates of cannabis use in patients with trauma-related disorders.
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Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD.
TL;DR: Evidence for the involvement of oxidative stress and inflammation in chronic PTSD and the neurobiological consequences of these processes, including accelerated cellular aging and neuroprogression are reviewed.
References
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Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
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