Journal ArticleDOI
Inhibition of the TetK efflux-pump by the essential oil of Chenopodium ambrosioides L. and α-terpinene against Staphylococcus aureus IS-58
Paulo W. Limaverde,Fábia F. Campina,Francisco Afrânio Cunha,Francidalva D. Crispim,Fernando Gomes Figueredo,Luciene Ferreira de Lima,Cícera Datiane de Morais Oliveira-Tintino,Yedda M.L.S. de Matos,Maria Flaviana Bezerra Morais-Braga,Irwin Rose Alencar de Menezes,Valdir de Queiroz Balbino,Henrique Douglas Melo Coutinho,José P. Siqueira-Júnior,Jackson Roberto Guedes da Silva Almeida,Saulo R. Tintino +14 more
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TLDR
A reduction in the Minimum Inhibitory Concentration (MIC) demonstrates that the C. ambrosioides L. essential oil is an effective option in the inhibition of the efflux pump present in these micro-organisms.About:
This article is published in Food and Chemical Toxicology.The article was published on 2017-11-01. It has received 73 citations till now. The article focuses on the topics: Chenopodium ambrosioides & Essential oil.read more
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Journal ArticleDOI
Efflux pump inhibitors for bacterial pathogens: From bench to bedside.
TL;DR: This review focuses on EPIs and identifies the challenges that have kept these futuristic therapeutics away from the commercial realm so far.
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A review of the current evidence of fruit phenolic compounds as potential antimicrobials against pathogenic bacteria.
Maiara da Costa Lima,C. Paiva de Sousa,Christopher Fernandez-Prada,Josée Harel,J D Dubreuil,E.L. de Souza +5 more
TL;DR: Results of available studies indicate the depolarization and alteration of membrane fluidity as mechanisms underlying the inhibition of pathogenicacteria by fruit PC, which reveal fruit PC have potential antimicrobial properties, which should be rationally exploited in solutions to control pathogenic bacteria.
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Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance.
TL;DR: Plant-based EPIs hold promise as potent drug-leads to combat the EPI-mediated AMR, and effective strategies for inhibiting drug EPs with phytomolecules for reversing their AMR characteristics are discussed.
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The alarming antimicrobial resistance in ESKAPEE pathogens: Can essential oils come to the rescue?
TL;DR: Possibility of using EOs directly for antimicrobial potentials or in combination with antibiotics to potentiate the later for combating AMR in ESKAPEE pathogens are discussed.
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The Antibiotic Resistome: A Guide for the Discovery of Natural Products as Antimicrobial Agents.
TL;DR: The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria to acquire and develop an array of antibiotic resistance mechanisms, the antibiotic resistome, is a formidable threat to antibiotic discovery, development, and use as discussed by the authors.
References
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Essential oils: their antibacterial properties and potential applications in foods--a review.
TL;DR: In vitro studies have demonstrated antibacterial activity of essential oils (EOs) against Listeria monocytogenes, Salmonella typhimurium, Escherichia coli O157:H7, Shigella dysenteria, Bacillus cereus and Staphylococcus aureus at levels between 0.2 and 10 microl ml(-1).
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Biological effects of essential oils - A review
TL;DR: Findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level.
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Mechanisms of membrane toxicity of hydrocarbons.
TL;DR: In this paper, the authors present general ideas derived from the various reports mentioning toxic effects of lipophilic compounds on the membrane lipid bilayer, affecting the structural and functional properties of these membranes.
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Multidrug-resistance efflux pumps ? not just for resistance
TL;DR: Evidence is presented that multidrug-resistance efflux pumps have roles in bacterial pathogenicity and it is proposed that these pumps therefore have greater clinical relevance than is usually attributed to them.
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Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
TL;DR: This review focuses on chromosomally encoded pumps in bacteria that cause infections in humans, and suggests that resistance nodulation division systems are important in pathogenicity and/or survival in a particular ecological niche.