Interleukin-22 promotes PD-L1 expression via STAT3 in colon cancer cells.
Xiangpeng Xi,Rui Hu,Qi Wang,Kang Xu,Hui Yang,Zhonghui Cui,Yongbo Zhang,Mujian Teng,Lijian Xia,Jingbo Chen,Yulin Liu +10 more
TLDR
In this article, exogenous IL-22 was found to upregulate PD-L1 expression via the signal transducer and activator of transcription 3 signaling pathway in human colon cancer cells.Abstract:
Blocking the expression of programmed cell death ligand 1 (PD-L1) is a promising approach for the treatment of colon cancer. The binding of PD-L1 to its receptor programmed cell death 1 (PD-1) on immune cells leads to the apoptosis of activated T cells and causes immune escape. However, there is a limited number of patients with colon cancer that can benefit from the inhibition of PD-L1, and the regulation of PD-L1 expression is poorly understood in colon cancer. The present study demonstrated that interleukin-22 (IL-22) and PD-L1 were upregulated in colon cancer tissues and there was a positive correlation between IL-22 expression and PD-L1 expression. In the present study, exogenous IL-22 was found to upregulate PD-L1 expression via the signal transducer and activator of transcription 3 signaling pathway in human colon cancer cells (DLD-1 and primary colon cancer cells). The results of the present study revealed a novel regulatory mechanism of PD-L1 expression in colon cancer, which provides a theoretical basis for decreasing the immune tolerance of colon cancer via IL-22 overexpression.read more
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PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma
Maria Davern,R. O. O' Brien,Jason Liang McGrath,Noel E Donlon,Ashanty M. Melo,Croí E. Buckley,Andrew Sheppard,John V. Reynolds,Niamh Lynam-Lennon,Stephen G. Maher,Joanne Lysaght +10 more
TL;DR: In this article , the authors reveal novel mechanistic insights into the immuneindependent functions of IC-intrinsic signalling in OAC cells with important clinical implications for boosting the efficacy of the first-line FLOT chemotherapy regimen in oesophageal adenocarcinoma (OAC) cells.
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Towards a precision immune checkpoint blockade immunotherapy in patients with colorectal cancer: Strategies and perspectives.
TL;DR: In this article , the authors focused on and discussed precision strategies and perspectives e.g., how to early define candidates who will benefit from ICB immunotherapy prior treatment, overcome the primary and acquired resistance and improve the therapeutic response to ICBs in CRC patients with different microsatellite-instability statuses within the context of precision medicine algorithm.
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Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells
C. Maresca,G. Di Maggio,Carmine Stolfi,Federica Laudisi,Marco Colella,T. Pacifico,Antonio Di Grazia,Davide Di Fusco,D. Congiu,Andrea Martina Guida,Giuseppe S. Sica,Ivan Monteleone,Giovanni Monteleone +12 more
TL;DR: First evidence supporting the theory that Smad7 positively regulates Stat3 function in CRC cells is presented, which delineate a novel positive feedback loop that sustains CRC cell behavior and suggest thatSmad7 is a target for therapeutic intervention in patients with such a disease.
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Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors
Xavier Thuru,Romain Magnez,Hassiba El-Bouazzati,Gérard Vergoten,Bruno Quesnel,Christian Bailly +5 more
TL;DR: Several types of drugs known to alter the checkpoint are reviewed, either directly via the blockade of PD-L1 or indirectly via an action on upstream effectors to suppress PD- L1 transcription or to induce its proteasomal degradation.
Journal ArticleDOI
Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications
TL;DR: In this paper , a review summarizes current new insights of cytokines, such as interleukin (IL)-4, IL-6, IL 8, IL 17A, IL 22, IL 23, IL 24 and interferon (IFN)-γ, involving in the modulation of pCSC/CSC properties and features in precancerous and cancerous lesions and discusses the possible mechanisms of adenoma progression to CRCs and their therapeutic potential.
References
More filters
Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray,Jacques Ferlay,Isabelle Soerjomataram,Rebecca L. Siegel,Lindsey A. Torre,Ahmedin Jemal +5 more
TL;DR: A status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions.
Journal ArticleDOI
Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study
Michael J. Overman,Ray McDermott,Joseph Leach,Sara Lonardi,Heinz-Josef Lenz,Michael A. Morse,Jayesh Desai,Andrew G. Hill,Michael D. Axelson,Rebecca A. Moss,Monica V. Goldberg,Z. Alexander Cao,Jean Marie Ledeine,G. Maglinte,Scott Kopetz,Thierry André +15 more
TL;DR: Nivolumab provided durable responses and disease control in pre-treated patients with dMMR/MSI-H metastatic colorectal cancer, and could be a new treatment option for these patients.
Journal ArticleDOI
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
Journal ArticleDOI
Regulation and Function of the PD-L1 Checkpoint
TL;DR: The roles of the PD-1-PD-L1 axis in cancer is reviewed, focusing on recent findings on the mechanisms that regulate PD-L 1 expression at the transcriptional, posttranscriptional, and protein level, to inform the design of more precise and effective cancer immune checkpoint therapies.