Introduction to NF-kappaB: players, pathways, perspectives.
TLDR
An overview of the discovery and current status of NF-κB as a research topic is provided and the organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-σB.Abstract:
This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-kappaB). It provides an overview of the discovery and current status of NF-kappaB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB signaling is primarily regulated by inhibitor kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappaB pathways. The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-kappaB.read more
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Oxidative Stress and Antioxidant Defense
TL;DR: In this review, the cellular oxidant and antioxidant systems are summarized and the cellular effects and mechanisms of the oxidative stress are discussed.
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Signaling to NF-κB by Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: The role of NF-κB in TLR signaling pathways has been discussed in this article, where the authors review recent progress in their understanding of the role and potential implications for molecular medicine.
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Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
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NF-κB, the first quarter-century: remarkable progress and outstanding questions
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: Despite the tremendous progress that has been made in understanding the regulation of NF-κB, there is much that remains to be understood and the fundamental questions that remain unanswered after 25 years of study are highlighted.
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The role of inflammation in epilepsy
TL;DR: This work focuses on the rapidly growing body of evidence that supports the involvement of inflammatory mediators—released by brain cells and peripheral immune cells—in both the origin of individual seizures and the epileptogenic process.
References
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Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
Ranjan Sen,David Baltimore +1 more
TL;DR: Phorbol-ester-mediated induction of NF-kappa B was observed in a T cell line and a nonlymphoid cell line, and is therefore not restricted to B-lymphoids cells, indicating that factors that control transcription of specific genes in specific cells may be activated by posttranslational modification of precursor factors present more widely.
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Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
TL;DR: It is concluded that both 70Z/3 and HeLa cells contain apparently cytosolic NF-kappa B in a form with no evident DNA-binding activity, and phorbol esters both release the inhibition of binding and cause a translocation to the nucleus.
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NF-kappaB and the immune response.
TL;DR: The role of the NF-κB pathway in the development and functioning of the immune system has been discussed in this article, where a review of the role of this pathway is presented.
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The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product
Mark W. Kieran,Volker Blank,Frédérique Logeat,Joël Vandekerckhove,Frledrich Lottspeich,Odile Le Bail,Manuela B. Urban,Philippe Kourilsky,Patrick A. Baeuerle,Alain Israël +9 more
TL;DR: A complementary cDNA coding for KBF1 is isolated and the DNA binding and dimerization domain of the protein is identified, which suggests functional homologies between KBF2 and v-rel and the Drosophila maternal morphogen dorsal.
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Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal
Sankar Ghosh,Ann M. Gifford,Lise R. Riviere,Paul Tempst,Garry P. Nolan,David Baltimore,David Baltimore +6 more
TL;DR: The DNA binding subunit of the transcription factor NF-kappa B, p50, has been cloned and sequence analysis reveals remarkable homology for over 300 amino acids at the amino-terminal end to the oncogene v-rel, its cellular homolog c-rel and the Drosophila maternal effect gene dorsal as mentioned in this paper.