Iron metabolism and its contribution to cancer (Review)
TLDR
Previous studies on the physiology of iron metabolism and its role in cancer are summarized and the significance of iron regulation, and the association between iron homeostasis and carcinogenic mechanisms are discussed.Abstract:
Iron is an essential element for biological processes. Iron homeostasis is regulated through several mechanisms, from absorption by enterocytes to recycling by macrophages and storage in hepatocytes. Iron has dual properties, which may facilitate tumor growth or cell death. Cancer cells exhibit an increased dependence on iron compared with normal cells. Macrophages potentially deliver iron to cancer cells, resulting in tumor promotion. Mitochondria utilize cellular iron to synthesize cofactors, including heme and iron sulfur clusters. The latter is composed of essential enzymes involved in DNA synthesis and repair, oxidation‑reduction reactions, and other cellular processes. However, highly increased iron concentrations result in cell death through membrane lipid peroxidation, termed ferroptosis. Ferroptosis, an emerging pathway for cancer treatment, is similar to pyroptosis, apoptosis and necroptosis. In the present review, previous studies on the physiology of iron metabolism and its role in cancer are summarized. Additionally, the significance of iron regulation, and the association between iron homeostasis and carcinogenic mechanisms are discussed.read more
Citations
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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma
Bufu Tang,Jinyu Zhu,Jie Li,Kai Fan,Yang Gao,Yang Gao,Shimiao Cheng,Chunli Kong,Chunli Kong,Liyun Zheng,Fazong Wu,Fazong Wu,Qiaoyou Weng,Qiaoyou Weng,Chenying Lu,Chenying Lu,Jiansong Ji,Jiansong Ji +17 more
TL;DR: The prognostic and diagnostic models based on the four genes indicated superior diagnostic and predictive performance, indicating new possibilities for individualized treatment of HCC patients.
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The function and mechanism of ferroptosis in cancer
TL;DR: The potential roles of ferroptosis in cancer, including those related to p53, noncoding RNA (ncRNA), and the tumor microenvironment (TME), are discussed to demonstrate the associations between ferroPTosis and cancer.
Journal ArticleDOI
Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers.
Bowen Li,Liang Yang,Xueqiang Peng,Qin Fan,Shibo Wei,Shuo Yang,Xinyu Li,Hongyuan Jin,Bo Wu,Mingyao Huang,Shilei Tang,Jingang Liu,Hangyu Li +12 more
TL;DR: This review focuses on the intrinsic cellular regulators against ferroptosis in cancer resistance, such as GPX4, NRF2 and the thioredoxin system, and the application of novel compounds and drugs to circumvent treatment resistance.
Journal ArticleDOI
Development and validation of a ferroptosis-related lncRNAs prognosis signature in colon cancer.
Hua Jun Cai,Zhi Cheng Zhuang,Yong Wu,Yi Yi Zhang,Xing Liu,Jin Fu Zhuang,Yuan Feng Yang,Yuan Gao,Bin Chen,Guo Xian Guan +9 more
TL;DR: In this paper, the authors investigated ferroptosis-related long non-coding RNAs (lncRNAs) and constructed a prognostic model for colon adenocarcinoma (COAD).
Journal ArticleDOI
Metabolic Reprogramming in Cancer is Induced to Increase Proton Production
Huiyan Sun,Huiyan Sun,Yi Zhou,Michael Skaro,Yiran Wu,Zexing Qu,Fenglou Mao,Suwen Zhao,Ying Xu,Ying Xu +9 more
TL;DR: Analysis of reprogrammed metabolisms including the Warburg effect, nucleotide de novo synthesis and sialic acid biosynthesis in cancer suggests that continuous cell division and other cancerous behaviors are ways for the affected cells to remove non-proton products in a timely and sustained manner.
References
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