Isolation and comparison of mesenchymal stem cell-like cells derived from human gastric cancer tissues and corresponding ovarian metastases
Kunyan Zhou,Man Xia,Bo Tang,Darong Yang,Nianli Liu,Dihong Tang,Hailong Xie,Xiaohong Wang,Haizhen Zhu,Chen Liu,Chaohui Zuo +10 more
TLDR
The existence of MSC-like cells in GC tissues and its ovarian metastatic tissues suggests that they may be a potential target for cancer therapy, and provides an experimental foundation for investigating their role in the initiation and progression of ovarian metastasis of GC.Abstract:
Mesenchymal stem cell (MSC)-like cells have been isolated from various types of tumor. It has previously been reported that MSCs are involved in tumorigenesis and its prognosis. The aim of the present study was to isolate and compare MSC-like cells from human gastric cancer (GC) and its metastatic deposits in ovarian tissue. MSC-like cells were isolated from human gastric cancer (hGC-MSCs) and the corresponding ovarian metastatic tissues (hGCOM-MSCs) from 40 patients. The characteristics of hGC-MSCs and hGCOM-MSCs, including their morphology, surface antigens, specific gene expression and differentiation potential, were similar to those of MSCs derived from human bone marrow (hBM-MSCs) but different from GC cells. In conclusion, the present study demonstrated that MSC-like cells could be isolated from GC tissue and its ovarian metastatic tissues. The existence of MSC-like cells in GC tissues and its ovarian metastatic tissues suggests that they may be a potential target for cancer therapy, and provides an experimental foundation for investigating their role in the initiation and progression of ovarian metastasis of GC.read more
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Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth
Maria E. Gonzalez,Emily E. Martin,Talha Anwar,Caroline Arellano-Garcia,Natasha Medhora,Arjun Lama,Yu Chih Chen,Kevin S. Tanager,Euisik Yoon,Kelley M. Kidwell,Chunxi Ge,Renny T. Franceschi,Celina G. Kleer +12 more
TL;DR: It is reported that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication and suggested a therapeutic approach for metastatic BC.
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Mesenchymal Stem Cells (MSCs) Therapy for Recovery of Fertility: a Systematic Review
TL;DR: The data obtained are promising, but the further studies need to assess the efficiency and safety of transplantation of these cells in fertility recovery as compared with the other types of MSCs.
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miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer
Min Ma,Shilin Chen,Zhuo Liu,Hailong Xie,Hongyu Deng,Song Shang,Xiaohong Wang,Man Xia,Chaohui Zuo +8 more
TL;DR: Extracted exosomes from BM-MSCs transfected with miR-221 oligonucleotides can act as high-efficiency nanocarriers, which can provide sufficientmiR- 221 oligon nucleotides to influence the tumor microenvironment and tumor aggressiveness effectively.
Journal ArticleDOI
Exosomal miRNA-1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer.
Song Shang,Jinfeng Wang,Shilin Chen,Renyun Tian,Hui Zeng,Liang Wang,Man Xia,Haizhen Zhu,Chaohui Zuo +8 more
TL;DR: The exosomes extracted from BM‐MSCs with high level of miR‐1231 inhibit the activity of PC, providing the potential application for developing new and efficient medicine for cancer therapy, especially for PC treatment.
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Tumor-derived mesenchymal-stem-cell-secreted IL-6 enhances resistance to cisplatin via the STAT3 pathway in breast cancer.
Huitao Xu,Ying Zhou,Wei Li,Bin Zhang,Huanhuan Zhang,Shaolin Zhao,Ping Zheng,Huiyi Wu,Jin Yang +8 more
TL;DR: The findings of the present study indicated that BC-MSCs decreased the level of cisplatin-induced apoptosis in MCF-7 cells by activating the IL-6/STAT3 pathway in cancer cells.
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