Journal ArticleDOI
Jury returns on structure prediction.
Burkhard Rost,Chris Sander +1 more
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This article is published in Nature.The article was published on 1992-12-10. It has received 80 citations till now. The article focuses on the topics: Jury.read more
Citations
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Combining evolutionary information and neural networks to predict protein secondary structure.
Burkhard Rost,Chris Sander +1 more
TL;DR: This work extends the previous three‐level system of neural networks by using additional input information derived from multiple alignments using a position‐specific conservation weight as part of the input to increase performance and greatly increased accuracy.
Journal ArticleDOI
The PredictProtein server
TL;DR: PredictProtein is an Internet service for sequence analysis and the prediction of protein structure and function that returns multiple sequence alignments, PROSITE sequence motifs, low-complexity regions (SEG), nuclear localization signals, regions lacking regular structure (NORS) and predictions of secondary structure, solvent accessibility, globular regions, transmembrane helices and functional annotations.
Journal ArticleDOI
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
David J. Rawlings,Douglas C. Saffran,Satoshi Tsukada,David A. Largaespada,J. Christopher Grimaldi,Lucie Cohen,Randolph N. Mohr,J. Fernando Bazan,Maureen C. Howard,Neal G. Copeland,Nancy A. Jenkins,Owen N. Witte +11 more
TL;DR: The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis and a single conserved residue within the amino terminal unique region of Btk was mutated in XID mice, probably interferes with normal B cell signaling mediated by Btk protein interactions.
Journal ArticleDOI
The modular architecture of a new family of growth regulators related to connective tissue growth factor
TL;DR: In this article, the authors characterized and sequenced members of a new family of growth regulators (originally called cef10, connective tissue growth factor, fisp-12, cyr61, or, alternatively, βIG-M1 and βG-M2), all of which belong to immediate-early genes expressed after induction by growth factors or certain oncogenes.
Journal ArticleDOI
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.
P.R. Baum,R.B. Gayle rd,F. Ramsdell,Subhashini Srinivasan,Rick Sorensen,Mark L. Watson,Michael F. Seldin,Elizabeth Baker,Grant R. Sutherland,K N Clifford +9 more
TL;DR: Strong induction of IL‐4 secretion by muOX40L suggests that this ligand may play a role in regulating immune responses, and the HTLV‐1 regulation of gp34 suggests a possible connection between virally induced pathogenesis and the OX40 system.
References
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Journal ArticleDOI
Crystal structure of a Src-homology 3 (SH3) domain.
TL;DR: The three-dimensional struc-ture at 1.8 Å resolution of the SH3 domain of the cytoskeletal protein spectrin expressed in Escherichia coli is reported and it is suggested that a protein ligand binds to this conserved surface of SH3.
Journal ArticleDOI
SH3--an abundant protein domain in search of a function.
TL;DR: Src‐homology 3 is a small protein domain of about 60 amino acid residues that is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane—cytoskeleton interactions.
Journal ArticleDOI
Prediction of progress at last
Journal ArticleDOI
Correct structure prediction
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