Kaempferol is an estrogen-related receptor α and γ inverse agonist.
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PGC‐1 alpha and ERR gamma bind by surface plasmon resonance to form H2O2 ’s ‘spatially reprograming signal’.Citations
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A review on the dietary flavonoid kaempferol.
José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Concepción Pérez-Guerrero,Miguel López-Lázaro +3 more
TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
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Flavonoids as Anticancer Agents
TL;DR: Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways.
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Kaempferol, a potential cytostatic and cure for inflammatory disorders.
Peramaiyan Rajendran,Thamaraiselvan Rengarajan,Natarajan Nandakumar,Rajendran Palaniswami,Yutaka Nishigaki,Ikuo Nishigaki +5 more
TL;DR: The anti-oxidant/anti-inflammatory and anticancer effects of kaempferol are summarized with a focus on its molecular targets and the possible use of this flavonoid for the treatment of inflammatory diseases and cancer.
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A structural view of nuclear hormone receptor: endocrine disruptor interactions
TL;DR: This work reviews recent studies showing the many ways in which EDCs interact with NHRs and impact their signaling pathways and suggests structure-based knowledge can be used to predict the endocrine-disrupting potential of environmental pollutants and may have applications in drug discovery.
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Polyphenols as mitochondria-targeted anticancer drugs
TL;DR: Polyphenols of plant origin and their synthetic or semisynthetic derivatives exhibit pleiotropic biological activities, including the modes of action characteristic of mitocans, which have been synthesized and reported to efficiently induce cancer cell death in vitro.
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The RXR heterodimers and orphan receptors
TL;DR: The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented.
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DIETARY FLAVONOIDS: Bioavailability, Metabolic Effects, and Safety
Julie A. Ross,Christine M. Kasum +1 more
TL;DR: Investigation in the possible health benefits of flavonoids has increased owing to their potent antioxidant and free-radical scavenging activities observed in vitro, and there is growing evidence from human feeding studies that the absorption and bioavailability of specific flavonoid is much higher than originally believed.
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Orphan nuclear receptors: from gene to function.
TL;DR: I. Nuclear Receptors: General Concepts and Orphans in Search of a Home.
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Transcriptional control of energy homeostasis by the estrogen-related receptors.
TL;DR: Recent and rapid advances in understanding the functions of the ERRs in regulating bioenergetic pathways are reviewed, with an emphasis on their roles in the specification of energetic properties required for cell- and tissue-specific functions.
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Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ IDENTIFICATION OF NOVEL LEUCINE-RICH INTERACTION MOTIF WITHIN PGC-1α
TL;DR: The results identify ERRα and ERRγ as novel PGC-1α interacting proteins, implicate ERR isoforms in the regulation of mitochondrial energy metabolism, and suggest a potential mechanism whereby P GC-1 α selectively binds transcription factor partners.