Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection

TLDR: In lymphoid tissue, where human immunodeficiency virus-type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden as mentioned in this paper.

Abstract: In lymphoid tissue, where human immunodeficiency virus–type 1 (HIV-1) is produced and stored, three-drug treatment with viral protease and reverse transcriptase inhibitors markedly reduced viral burden. This was shown by in situ hybridization and computerized quantitative analysis of serial tonsil biopsies from previously untreated adults. The frequency of productive mononuclear cells (MNCs) initially diminished with a half-life of about 1 day. Surprisingly, the amount of HIV-1 RNA in virus trapped on follicular dendritic cells (FDCs) decreased almost as quickly. After 24 weeks, MNCs with very few copies of HIV-1 RNA per cell were still detectable, as was proviral DNA; however, the amount of FDC-associated virus decreased by ≥3.4 log units. Thus, 6 months of potent therapy controlled active replication and cleared >99.9 percent of virus from the secondary lymphoid tissue reservoir.

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Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1
infection
Cavert, W.; Notermans, D.W.; Staskus, K.; Wietgrefe, S.W.; Zupancic, N.; Gebhard, K.;
Henry, K.; Zhang, Z.Q.; Mills, R.; McDade, H.; Goudsmit, J.; Danner, S.A.; Haase, A.T.
DOI
10.1126/science.276.5314.960
Publication date
1997
Published in
Science
Link to publication
Citation for published version (APA):
Cavert, W., Notermans, D. W., Staskus, K., Wietgrefe, S. W., Zupancic, N., Gebhard, K.,
Henry, K., Zhang, Z. Q., Mills, R., McDade, H., Goudsmit, J., Danner, S. A., & Haase, A. T.
(1997). Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection.
Science
,
276
, 960-964. https://doi.org/10.1126/science.276.5314.960
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Download date:09 Aug 2022