Late presentation of HIV infection: a consensus definition
Andrea Antinori,T Coenen,D Costagiola,N. Dedes,M. Ellefson,Jose M. Gatell,Enrico Girardi,Margaret Johnson,Ole Kirk,Jens D Lundgren,Amanda Mocroft,A d'Arminio Monforte,Andrew N. Phillips,Dorthe Raben,Jürgen K. Rockstroh,Caroline A. Sabin,Anders Sönnerborg,F. De Wolf +17 more
TLDR
A consensus definition of late presentation of HIV infection is presented to present to identify the extent to which late presentation occurs remains inadequate across Europe.Abstract:
Objectives Across Europe, almost a third of individuals infected with HIV do not enter health care until late in the course of their infection. Surveillance to identify the extent to which late presentation occurs remains inadequate across Europe and is further complicated by the lack of a common clinical definition of late presentation. The objective of this article is to present a consensus definition of late presentation of HIV infection.
Methods Over the past year, two initiatives have moved towards a harmonized definition. In spring 2009, they joined efforts to identify a common definition of what is meant by a ‘late-presenting’ patient.
Results Two definitions were agreed upon, as follows. Late presentation: persons presenting for care with a CD4 count below 350 cells/μL or presenting with an AIDS-defining event, regardless of the CD4 cell count. Presentation with advanced HIV disease: persons presenting for care with a CD4 count below 200 cells/μL or presenting with an AIDS-defining event, regardless of the CD4 cell count.
Conclusion The European Late Presenter Consensus working group believe it would be beneficial if all national health agencies, institutions, and researchers were able to implement this definition (either on its own or alongside their own preferred definition) when reporting surveillance or research data relating to late presentation of HIV infection.read more
Citations
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Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE).
Amanda Mocroft,Jens D Lundgren,Jens D Lundgren,Miriam Lewis Sabin,Antonella d'Arminio Monforte,Norbert H. Brockmeyer,Jordi Casabona,Antonella Castagna,Dominique Costagliola,Dominique Costagliola,François Dabis,François Dabis,Stéphane De Wit,Gerd Fätkenheuer,Hansjakob Furrer,Anne A.M. Johnson,Marios M.K. Lazanas,Catherine Leport,Catherine Leport,Santiago Moreno,Niels Obel,Frank A. Post,Joanne Reekie,Joanne Reekie,Peter Reiss,Caroline A. Sabin,Adriane Skaletz-Rorowski,Ignacio Suárez-Lozano,Carlo Torti,Josiane Warszawski,Robert Zangerle,Céline Fabre-Colin,Céline Fabre-Colin,Jesper Kjaer,Geneviève Chêne,Geneviève Chêne,Jesper Grarup,Ole Kirk,Ole Kirk +38 more
TL;DR: Amanda Mocroft and colleagues investigate risk factors and health outcomes associated with diagnosis at a late stage of infection in individuals across Europe.
Journal ArticleDOI
British HIV Association guidelines for the routine investigation and monitoring of adult HIV‐1‐infected individuals 2011
David Asboe,C Aitken,Marta Boffito,Clare Booth,Patricia A. Cane,Ade Fakoya,Anna Maria Geretti,Peter Kelleher,Nicola Mackie,D Muir,Gary Murphy,Chloe Orkin,Frank A. Post,G Rooney,Caroline A. Sabin,Lorraine Sherr,Erasmus Smit,W Tong,A Ustianowski,M Valappil,J Walsh,Matthew Williams,D Yirrell +22 more
TL;DR: This review concludes that routine monitoring on ART for HIV‐infected patients and individuals transferring care from a different HIV healthcare setting is a viable option and should be considered.
Journal ArticleDOI
Life expectancy in HIV-positive persons in Switzerland: matched comparison with general population.
Aysel Gueler,André Moser,Alexandra Calmy,Huldrych F. Günthard,Enos Bernasconi,Hansjakob Furrer,Christoph A Fux,Manuel Battegay,Matthias Cavassini,Pietro Vernazza,Marcel Zwahlen,Matthias Egger +11 more
TL;DR: In Switzerland, educational inequalities in life expectancy were larger among HIV-infected persons than in the general population, and highly educated HIV-positive people have an estimated life expectancy similar to Swiss residents with compulsory education.
Journal ArticleDOI
Significant association between perceived HIV related stigma and late presentation for HIV/AIDS care in low and middle-income countries: A systematic review and meta-analysis
Hailay Abrha Gesesew,Hailay Abrha Gesesew,Amanuel Tesfay Gebremedhin,Tariku Dejene Demissie,Mirkuzie Woldie Kerie,Morankar Sudhakar,Lillian Mwanri +6 more
TL;DR: High perceptions of HIV related stigma influenced timely presentation for HIV care and health professionals should play a key role in informing and counselling patients on the benefits of early HIV testing or early entry to HIV care.
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