Lectins: production and practical applications
Sze-Kwan Lam,Tzi Bun Ng +1 more
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TLDR
Lectins manifest a diversity of activities including antitumor, immunomodulatory, antifungal, HIV-1 reverse transcriptase inhibitory, and anti-insect activities, which may find practical applications.Abstract:
Lectins are proteins found in a diversity of organisms. They possess the ability to agglutinate erythrocytes with known carbohydrate specificity since they have at least one non-catalytic domain that binds reversibly to specific monosaccharides or oligosaccharides. This articles aims to review the production and practical applications of lectins. Lectins are isolated from their natural sources by chromatographic procedures or produced by recombinant DNA technology. The yields of animal lectins are usually low compared with the yields of plant lectins such as legume lectins. Lectins manifest a diversity of activities including antitumor, immunomodulatory, antifungal, HIV-1 reverse transcriptase inhibitory, and anti-insect activities, which may find practical applications. A small number of lectins demonstrate antibacterial and anti-nematode activities.read more
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Antinutritional Factors in Plant Foods: Potential Health Benefits and Adverse Effects
TL;DR: The updated scientific information regarding the potential health benefits and adverse effects associated with major antinutritional factors found in plant foods is reviewed.
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Uncovering Potential Applications of Cyanobacteria and Algal Metabolites in Biology, Agriculture and Medicine: Current Status and Future Prospects
Rachana Singh,Parul Parihar,Madhulika Singh,Andrzej Bajguz,Jitendra Kumar,Samiksha Singh,Vijay Pratap Singh,Sheo Mohan Prasad +7 more
TL;DR: In this review, an endeavor has been made to uncover the significance of various metabolites like phenolics, phytoene/terpenoids, phytols, sterols, free fatty acids, photoprotective compounds, etc., which have several biotechnological, industrial, pharmaceutical, and cosmetic uses.
Journal ArticleDOI
Plant lectins: targeting programmed cell death pathways as antitumor agents.
TL;DR: It is demonstrated that mistletoe lectins, Ricin, Concanavalin A (ConA) and Polygonatum cyrtonema lectin (PCL) can lead to cancer cell programmed death via targeting apoptotic pathways, and it is shown that ConA and PCL can also result in cancercell programmed death by targeting autophagic pathways.
Journal ArticleDOI
Effect of extrusion on the anti-nutritional factors of food products: An overview
Nooshin Nikmaram,Sze Ying Leong,Mohamed Koubaa,Zhenzhou Zhu,Francisco J. Barba,Ralf Greiner,Indrawati Oey,Shahin Roohinejad +7 more
TL;DR: In this article, the authors highlight the effectiveness of extrusion processing in reducing various anti-nutritional factors (ANFs) of legumes and cereals, such as phytate, tannins and enzyme inhibitors.
Journal ArticleDOI
Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications
Luana Cassandra Breitenbach Barroso Coelho,Priscila Marcelino dos Santos Silva,Vera Lúcia de Menezes Lima,Emmanuel Viana Pontual,Patrícia Maria Guedes Paiva,Thiago Henrique Napoleão,Maria Tereza dos Santos Correia +6 more
TL;DR: This work addresses lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.
References
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Journal ArticleDOI
Hevein: an antifungal protein from rubber-tree (Hevea brasiliensis) latex
TL;DR: Several chitin-binding proteins were isolated from the “bottom fraction” of Hevea brasiliensis (Müll.) Arg.
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Antimicrobial Peptides From Amaranthus Caudatus Seeds With Sequence Homology to the Cysteine/Glycine-Rich Domain of Chitin-Binding Proteins
Willem F. Broekaert,Mariën W,Franky R. G. Terras,De Bolle Mf,Paul Proost,Van Damme J,L. Dillen,Magda Claeys,Sarah Bronwen Rees,Jozef Vanderleyden +9 more
TL;DR: Ac-AMP1 and Ac-AMP2 inhibit the growth of different plant pathogenic fungi at much lower doses than other known antifungal chitin-binding proteins and show some activity on Gram-positive bacteria.
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Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Els Keyaerts,Leen Vijgen,Christophe Pannecouque,Els J.M. Van Damme,Willy J. Peumans,Herman Egberink,Jan Balzarini,Marc Van Ranst +7 more
TL;DR: The antiviral activity of plant lectins with specificity for different glycan structures against the severe acute respiratory syndrome coronavirus (SARS-CoV) and the feline infectious peritonitis virus (FIPV) in vitro is described.
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A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication
TL;DR: BanLec is a potential component for an anti-viral microbicide that could be used to prevent the sexual transmission of HIV-1 and compared favorably to other anti-HIV lectins and to T-20 and maraviroc, two anti-hIV drugs currently in clinical use.
Journal ArticleDOI
Isolation of a homodimeric lectin with antifungal and antiviral activities from red kidney bean (Phaseolus vulgaris) seeds.
TL;DR: A homodimeric lectin adsorbed on Affi-gel blue gel and CM-Sepharose and possessing a molecular weight of 67 kDa was isolated from red kidney beans and exhibited some differences from previously reported lectins from Phaseolus vulgaris but showed some similarity to chitinases.
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