Lipid concentrations and semen quality: the LIFE study.
Enrique F. Schisterman,Sunni L. Mumford,Zhen Chen,Richard W. Browne,D. Boyd Barr,Sungduk Kim,G.M. Buck Louis +6 more
TLDR
It is found that higher levels of serum total cholesterol, free cholesterol and phospholipids were associated with a significantly lower percentage of spermatozoa with intact acrosome and smaller sperm head area and perimeter.Abstract:
The decline in sperm count rates over the last 50 years appears to parallel the rising prevalence of obesity. As lipid levels are strongly associated with obesity, high lipids levels or hyperlipidaemia may thus play an important role in the decline in fertility in addition to other environmental or lifestyle factors. The objective of this population based cohort study was to evaluate the association between men's serum lipid concentrations and semen quality parameters among 501 male partners of couples desiring pregnancy and discontinuing contraception. Each participant provided prospectively up to two semen samples (94% of men provided one or more semen samples, and 77% of men provided a second sample approximately 1 month later). Linear mixed effects models were used to estimate the associations between baseline lipid concentrations and semen quality parameters, adjusted for age, body mass index and race. We found that higher levels of serum total cholesterol, free cholesterol and phospholipids were associated with a significantly lower percentage of spermatozoa with intact acrosome and smaller sperm head area and perimeter. Our results suggest that lipid concentrations may affect semen parameters, specifically sperm head morphology, highlighting the importance of cholesterol and lipid homeostasis for male fecundity.read more
Citations
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Dietary fatty acids affect semen quality: a review.
TL;DR: Although improvements in sperm parameters are a response to omega‐3 sources after more than 4 weeks of supplementation in the male diet, time‐dependent and dose‐dependent responses may explain the failure in some experiments.
Journal ArticleDOI
Male infertility as a window to health.
TL;DR: There is an emerging body of evidence suggesting that male infertility may be a harbinger of future health, and additional research is required to elucidate the mechanisms by which male infertility affects overall health.
Journal ArticleDOI
Obesity, a serious etiologic factor for male subfertility in modern society.
Yue Liu,Zhide Ding +1 more
TL;DR: How obesity-related changes in males to influence sperm function and male fertility as well is explained.
Journal ArticleDOI
Melatonin and male reproduction.
Chunjin Li,Xu Zhou +1 more
TL;DR: Overall, the literature data indicate that melatonin affects the secretion of both gonadotropins and testosterone while also improving sperm quality, implying that it has important effects on the regulation of testicular development and male reproduction.
Journal ArticleDOI
Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study
TL;DR: A negative relationship among occupational exertion, hypertension, and the number of medications with semen quality was identified, and further research should determine whether treatment or cessation may improve male fecundity.
References
More filters
Journal ArticleDOI
Anthropometric standardization reference manual
TL;DR: This abridged version of the "Anthropometric Standardisation Reference Manual" contains the heart of the original manual - complete procedures for 45 anthropometric measurements.
Journal ArticleDOI
Overweight and obesity in the United States: prevalence and trends, 1960–1994
TL;DR: Between 1976–80 and 1988–94, the prevalence of obesity (BMI≥30.0) increased markedly in the US, in agreement with trends seen elsewhere in the world.
Journal ArticleDOI
World Health Organization reference values for human semen characteristics
Trevor G. Cooper,Elizabeth A. Noonan,Sigrid von Eckardstein,Jacques Auger,H.W. Gordon Baker,Hermann M. Behre,Trine B. Haugen,Thinus F. Kruger,Christina Wang,Michael T. Mbizvo,Kirsten M. Vogelsong +10 more
TL;DR: Semen quality of the reference population was superior to that of the men from the general population and normozoospermic men, and provide an appropriate tool in conjunction with clinical data to evaluate a patient's semen quality and prospects for fertility.
Journal ArticleDOI
Testicular dysgenesis syndrome ; an increasingly common developmental disorder with environmental aspects
TL;DR: Existing evidence supporting a new concept that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the testicular dysgenesis syndrome (TDS), which may be increasingly common due to adverse environmental influences is summarized.
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