Journal ArticleDOI
Lipoprotein Lipase and Its Regulators: An Unfolding Story.
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TLDR
This work has shown that the discovery of several new regulators such as glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed the understanding of LPL biology.Abstract:
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the 1940s, its biology and pathophysiological significance have been well characterized. Nonetheless, several studies in the past decade, with recent delineation of LPL crystal structure and the discovery of several new regulators such as angiopoietin-like proteins (ANGPTLs), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed our understanding of LPL biology.read more
Citations
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Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society
Henry N. Ginsberg,Chris J. Packard,M. John Chapman,Jan Borén,Carlos A. Aguilar-Salinas,Maurizio Averna,Brian A. Ference,Daniel Gaudet,Robert A. Hegele,Sander Kersten,Gary F. Lewis,Alice H. Lichtenstein,Philippe Moulin,Børge G. Nordestgaard,Børge G. Nordestgaard,Alan T. Remaley,Bart Staels,Erik S.G. Stroes,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen,Jane K Stock,Alberico L. Catapano +22 more
TL;DR: In this paper, a conceptual framework for the generation of remnants due to dysregulation of TRL production, lipolysis, and remodelling, as well as clearance of remnant lipoproteins from the circulation, and challenges in defining, quantifying, and assessing the atherogenic properties of remnant particles.
Journal ArticleDOI
Metabolic-associated fatty liver disease and lipoprotein metabolism.
Joerg Heeren,Ludger Scheja +1 more
TL;DR: In this article, a review article discusses recent research addressing hepatic lipid synthesis, VLDL production, and lipoprotein internalization as well as the lipid exchange between adipose tissue and the liver in the context of metabolic-associated fatty liver disease.
Journal ArticleDOI
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia
TL;DR: An overview of the pathways involved in triglyceride-rich lipoprotein (TRL) assembly and intravascular processing is provided, and how the dysregulation of triglyceride transport can result in hypertriglyceridaemia is discussed.
Journal ArticleDOI
An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues.
Ren Zhang,Kezhong Zhang +1 more
TL;DR: In this paper, the authors proposed a model to explain the post-prandial activity of Lipoprotein lipase (LPL) in the fed-fast cycle and showed that A8 antagonism has the potential to simultaneously reduce TG and increase HDL-cholesterol plasma levels.
Journal ArticleDOI
An updated ANGPTL3-4-8 model as a mechanism of triglyceride partitioning between fat and oxidative tissues
TL;DR: In this paper , the authors proposed a model to explain the post-prandial activity of Lipoprotein lipase (LPL) in the fed-fast cycle and showed that A8 antagonism has the potential to simultaneously reduce TG and increase HDL-cholesterol plasma levels.
References
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Journal ArticleDOI
An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Len A. Pennacchio,Michael Olivier,Jaroslav A. Hubacek,Jonathan Cohen,David R. Cox,Jean-Charles Fruchart,Ronald M. Krauss,Edward M. Rubin +7 more
TL;DR: Findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.
Journal ArticleDOI
Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart.
Journal ArticleDOI
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.
Kiran Musunuru,James P. Pirruccello,James P. Pirruccello,James P. Pirruccello,Ron Do,Ron Do,Ron Do,Gina M. Peloso,Gina M. Peloso,Candace Guiducci,Carrie Sougnez,Kiran V. Garimella,Sheila Fisher,Justin Abreu,Andrew Barry,Timothy Fennell,Eric Banks,Lauren Ambrogio,Kristian Cibulskis,Andrew Kernytsky,Elena Gonzalez,Nicholas Rudzicz,James C. Engert,Mark A. DePristo,Mark J. Daly,Mark J. Daly,Jonathan C. Cohen,Helen H. Hobbs,David Altshuler,David Altshuler,Gustav Schonfeld,Stacey Gabriel,Pin Yue,Sekar Kathiresan,Sekar Kathiresan +34 more
TL;DR: The finding of ANGPTL3 mutations highlights a role for the gene in LDL cholesterol metabolism in humans and shows the usefulness of exome sequencing for identification of novel genetic causes of inherited disorders.
Journal ArticleDOI
A specific apoprotein activator for lipoprotein lipase.
TL;DR: Only apoLP-glu is able to stimulate LPL activity in the absence of phospholipid and, in the presence of phosphoipid, increases activity twelvefold over baseline levels.
Journal ArticleDOI
Hypertriglyceridemia associated with deficiency of apolipoprotein C-II.
TL;DR: A 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity was studied and it is concluded that this patient's hyperlipoproteinemia resulted from a deficiency of apolipoprotein C-II.
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