Journal ArticleDOI
Liver-targeting of primaquine-(poly-γ-glutamic acid) and its degradation in rat hepatocytes
Noboru Tomiya,Juliette G. Jardim,Jennifer Hou,Rebecca Pastrana-Mena,Rhoel R. Dinglasan,Yuan C. Lee +5 more
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TLDR
The results described in this report suggest that the TriGalNAc ligand can serve as an excellent targeting device for delivery of PGA-conjugates to the liver hepatocytes, and rat hepatocytes possess sufficient capacity to digest PGA even modified with other substituents.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2013-09-01. It has received 24 citations till now. The article focuses on the topics: Asialoglycoprotein receptor & Conjugate.read more
Citations
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Journal ArticleDOI
Asialoglycoprotein receptor mediated hepatocyte targeting - strategies and applications.
TL;DR: Various ligands and nanocarriers exploited for ASGPR mediated delivery of drugs to hepatocytes provide great promise for improved therapy of hepatic afflictions and applications in diagnostics are highlighted.
Patent
Conjugated antisense compounds and their use
TL;DR: In this paper, oligomeric compounds with conjugate groups are conjugated to N-Acetylgalactosamine, and they are shown to be stable.
Journal ArticleDOI
"Recycling" classical drugs for malaria.
Patent
Oligomer-conjugate complexes and their use
TL;DR: Oligonucleotides, chemically modified oligonucleotide-conjugate compounds, and oligonuclear compounds are used in research, diagnostics, and/or therapeutics as discussed by the authors.
Journal ArticleDOI
Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins
TL;DR: In this article, the authors exploited the potential of the asialoglycoprotein receptor (ASGPR), a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins.
References
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Journal ArticleDOI
A research agenda to underpin malaria eradication.
Pedro L. Alonso,Graham Brown,Myriam Arévalo-Herrera,Fred Binka,Chetan E. Chitnis,Frank H. Collins,Ogobara K. Doumbo,Brian Greenwood,B. Fenton Hall,Myron M. Levine,Kamini Mendis,Robert D. Newman,Christopher V. Plowe,Mario Henry Rodriguez,Robert E. Sinden,Laurence Slutsker,Marcel Tanner +16 more
TL;DR: The Malaria Eradication Research Agenda initiative and the set of articles published in this PLoS Medicine Supplement that distill the research questions key to malaria eradication are introduced.
Journal ArticleDOI
Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.
Journal ArticleDOI
Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting
TL;DR: The results obtained indicated that galactose coating of PPI systems increases the drug entrapment efficiency by 5-15 times depending upon generations, which can make the P PI systems more effective and suitable for targeted delivery of Primaquine phosphate to liver.
Journal ArticleDOI
The role of anti-malarial drugs in eliminating malaria
TL;DR: More evidence is needed on the safety of primaquine when administered without screening for G6PD deficiency to inform individual and mass treatment approaches in the context of malaria elimination programmes.
Journal ArticleDOI
Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes.
C J Steer,G Ashwell +1 more
TL;DR: Results provide clear evidence for the stability of the binding receptor under conditions where the ligand is being continually destroyed and support the previously proposed recycling hypothesis.