Localization of a Portion of Extranuclear ATM to Peroxisomes
Dianne Watters,Padmini Kedar,Kevin J. Spring,Jonas Carl-Otto Bjorkman,Phil Chen,Magtouf Gatei,Geoff W. Birrell,Bernadette Garrone,Priyadashini Srinivasa,Denis I. Crane,Martin F. Lavin +10 more
Reads0
Chats0
TLDR
It is demonstrated that a portion of ATM co-localizes with catalase, that ATM is present in purified mouse peroxisomes, and that there are reduced levels of ATM in the post-mitochondrial membrane fraction of cells from a patient with a peroxISome biogenesis disorder.About:Â
This article is published in Journal of Biological Chemistry.The article was published on 1999-11-26 and is currently open access. It has received 186 citations till now. The article focuses on the topics: Peroxisome & DNA damage.read more
Citations
More filters
Journal ArticleDOI
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh,Yael Ziv +1 more
TL;DR: Evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress and it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.
Journal ArticleDOI
ATM Activation by Oxidative Stress
TL;DR: It is shown that oxidation of ATM directly induces ATM activation in the absence of DNA DSBs and the MRN complex, and that ATM is an important sensor of reactive oxygen species in human cells.
Journal ArticleDOI
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
TL;DR: First described over 80 years ago, ataxia-telangiectasia (A-T) is a paradigm for cancer predisposition and neurodegenerative disorders and has a central role in the understanding of the DNA-damage response, signal transduction and cell-cycle control.
Journal ArticleDOI
ATM and ATR: networking cellular responses to DNA damage.
TL;DR: The protein kinases ATM and ATR are master controllers of some of these networks, acting either in concert or separately to orchestrate the responses to specific types of DNA damage or stalled replication.
Journal ArticleDOI
Recombinational DNA repair and human disease.
Larry H. Thompson,David Schild +1 more
TL;DR: The genes and proteins related to the homologous recombinational repair (HRR) pathway that are implicated in cancer through either genetic disorders that predispose to cancer through chromosome instability or the occurrence of somatic mutations that contribute to carcinogenesis are reviewed.
References
More filters
Journal ArticleDOI
A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase.
Roland F. Beers,Irwin W. Sizer +1 more
TL;DR: A quantitative, spectrophotometric technique for following the breakdown of hydrogen peroxide has been developed for routine studies of catalase kinetics and appears to give lower values forCatalase activity than do titration techniques.
Journal ArticleDOI
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Michael B. Kastan,Qimin Zhan,Wafik S. El-Deiry,Tyler Jacks,William V. Walsh,Beverly Plunkett,Bert Vogelstein,Albert J. Fornace +7 more
TL;DR: Three participants are identified (AT gene(s), p53, and GADD45) in a signal transduction pathway that controls cell cycle arrest following DNA damage; abnormalities in this pathway probably contribute to tumor development.
Journal ArticleDOI
A single ataxia telangiectasia gene with a product similar to pi-3 kinase
Kinneret Savitsky,Anat Bar-Shira,Shlomit Gilad,Galit Rotman,Yael Ziv,Lina Vanagaite,Danilo A. Tagle,Sara Smith,Tamar Uziel,Sharon Sfez,Maya Ashkenazi,Iris Pecker,Moshe Frydman,Reli Harnik,Sankhavaram R. Patanjali,Andrew D. Simmons,Gregory A. Clines,Adam Sartiel,Richard A. Gatti,Luciana Chessa,Ozden Sanal,Martin F. Lavin,Nicolaas G. J. Jaspers,A. Malcolm R. Taylor,Colin F. Arlett,Toru Miki,Sherman M. Weissman,Michael Lovett,Francis S. Collins,Yosef Shiloh +29 more
TL;DR: A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia was identified by positional cloning on chromosome 11q22-23 and encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control.
Journal ArticleDOI
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Carrolee Barlow,Shinji Hirotsune,Richard Paylor,Marek Liyanage,Michael Eckhaus,Francis J Collins,Yosef Shiloh,Jacqueline N. Crawley,Thomas Ried,Danilo A. Tagle,Anthony Wynshaw-Boris +10 more
TL;DR: Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder.
Journal ArticleDOI
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
TL;DR: Findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes, including meiosis, the normal growth of somatic tissues, immune development, and tumor suppression.
Related Papers (5)
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
A single ataxia telangiectasia gene with a product similar to pi-3 kinase
Kinneret Savitsky,Anat Bar-Shira,Shlomit Gilad,Galit Rotman,Yael Ziv,Lina Vanagaite,Danilo A. Tagle,Sara Smith,Tamar Uziel,Sharon Sfez,Maya Ashkenazi,Iris Pecker,Moshe Frydman,Reli Harnik,Sankhavaram R. Patanjali,Andrew D. Simmons,Gregory A. Clines,Adam Sartiel,Richard A. Gatti,Luciana Chessa,Ozden Sanal,Martin F. Lavin,Nicolaas G. J. Jaspers,A. Malcolm R. Taylor,Colin F. Arlett,Toru Miki,Sherman M. Weissman,Michael Lovett,Francis S. Collins,Yosef Shiloh +29 more