Long-term incidence of microvascular disease after bariatric surgery or usual care in patients with obesity, stratified by baseline glycaemic status: a post-hoc analysis of participants from the Swedish Obese Subjects study.
Lena M. S. Carlsson,Kajsa Sjöholm,Cecilia Karlsson,Cecilia Karlsson,Peter Jacobson,Johanna C. Andersson-Assarsson,Per-Arne Svensson,Ingrid Larsson,Ingrid Larsson,Stephan Hjorth,Martin Neovius,Magdalena Taube,Björn Carlsson,Björn Carlsson,Markku Peltonen +14 more
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TLDR
Surgery was associated with reduced incidence of microvascular events in people with prediabetes regardless of whether they developed diabetes during follow-up, and effective non-surgical treatments need to be developed for this purpose.About:
This article is published in The Lancet Diabetes & Endocrinology.The article was published on 2017-04-01 and is currently open access. It has received 102 citations till now. The article focuses on the topics: Prediabetes & Type 2 diabetes.read more
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Association of Metabolic Surgery With Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes and Obesity.
Ali Aminian,Alexander Zajichek,David Arterburn,Kathy Wolski,Stacy A. Brethauer,Stacy A. Brethauer,Philip R. Schauer,Michael W. Kattan,Steven E. Nissen +8 more
TL;DR: Among patients with type 2 diabetes and obesity, metabolic surgery, compared with nonsurgical management, was associated with a significantly lower risk of incident MACE, including mortality.
Journal ArticleDOI
Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial.
Geltrude Mingrone,Geltrude Mingrone,Geltrude Mingrone,Simona Panunzi,Andrea De Gaetano,Caterina Guidone,Caterina Guidone,Amerigo Iaconelli,Amerigo Iaconelli,Esmeralda Capristo,Esmeralda Capristo,Ghassan Chamseddine,Stefan R. Bornstein,Francesco Rubino,Francesco Rubino +14 more
TL;DR: A 10-year follow-up study of an open-label, single-centre (tertiary hospital in Rome, Italy), randomised controlled trial, in which patients with type 2 diabetes (baseline duration >5 years; glycated haemoglobin [HbA1c] >7·0, and body-mass index ≥35 kg/m2) were randomly assigned to medical therapy, Roux-en-Y gastric bypass (RYGB), or biliopancreatic diversion (BPD) by a computerised system RE
Journal ArticleDOI
Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences.
TL;DR: This Perspective reviews evidence that the relationship between hyperglycemia and microvascular dysfunction (MVD) is bidirectional and constitutes a vicious cycle and Pharmacological interventions to improve MVD are an active area of investigation.
Journal ArticleDOI
Gene-Diet Interaction and Precision Nutrition in Obesity.
Yoriko Heianza,Lu Qi,Lu Qi +2 more
TL;DR: Data from recent studies of gene-diet interactions are summarized, integration of research of metabolomics and gut microbiome is discussed, as well as potential application of the findings in precision nutrition.
Journal ArticleDOI
Obstructive Sleep Apnea and Obesity: Implications for Public Health.
Shazia Jehan,Ferdinand Zizi,Seithikurippu R. Pandi-Perumal,Steven Wall,Evan Auguste,Alyson K Myers,Girardin Jean-Louis,Samy I. McFarlane +7 more
TL;DR: The major preventable risk factors to decrease obesity are the awareness of lifestyle modification (eating behaviors, smoking, drinking alcohol, etc.) and understanding the importance of exercise as mentioned in this paper, which can significantly reduce the incidence of obesity, as well as OSA and the related comorbidities such as cardiovascular disease, atherosclerosis, and depression.
References
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Journal Article
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
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TL;DR: In this article, the effects of intensive blood-glucose control with either sulphonylurea or insulin and conventional treatment on the risk of microvascular and macrovascular complications in patients with type 2 diabetes in a randomised controlled trial were compared.
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TL;DR: It was deemed essential to develop an appropriate, uniform terminology and a functional, working classification of diabetes that reflects the current knowledge about the disease.
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Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Irene M Stratton,Amanda I Adler,H. Andrew W. Neil,David R. Matthews,Susan E. Manley,Carole A. Cull,D R Hadden,Robert C Turner,Rury R. Holman +8 more
TL;DR: In patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia, with the lowest risk being in those with HbA1c values in the normal range (<6.0%).
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10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
TL;DR: Despite an early loss of glycemic differences, a continued reduction in microvascular risk and emergent risk reductions for myocardial infarction and death from any cause were observed during 10 years of post-trial follow-up.
Journal ArticleDOI
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
Anushka Patel,Stephen MacMahon,John Chalmers,Bruce Neal,Laurent Billot,Mark Woodward,Mark Woodward,Michel Marre,Mark E. Cooper,Paul Glasziou,Paul Glasziou,Diederick E. Grobbee,Pavel Hamet,Stephen B. Harrap,Simon Heller,Lisheng Liu,Giuseppe Mancia,Carl Erik Mogensen,C. Y. Pan,Neil R Poulter,Anthony Rodgers,Bryan Williams,Severine Bompoint,Bastiaan E. de Galan,Bastiaan E. de Galan,Rohina Joshi,F. Travert +26 more
TL;DR: A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21%relative reduction in nephropathy.
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