Loss of iron triggers PINK1/Parkin‐independent mitophagy
TLDR
A mitophagy pathway is identified and characterized, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.Abstract:
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.read more
Citations
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Journal ArticleDOI
Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN
TL;DR:
Journal ArticleDOI
TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
Francois le Guerroué,Eric Bunker,William M. Rosencrans,Jack T. Nguyen,Mohammed Abul Basar,Achim Werner,Tsui-Fen Chou,Chunxin Wang,Richard J. Youle +8 more
TL;DR: In this paper , the authors demonstrate that the presence of ectopic TNIP1 negatively affects the rate of mitophagy. But they do not provide a molecular rationale for its inhibitory function during mitophagia.
Journal ArticleDOI
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts.
Gustav Godtliebsen,Kenneth Bowitz Larsen,Zambarlal Bhujabal,Ida Sundvor Opstad,Mireia Nàger,Abhinanda R. Punnakkal,Trine Kalstad,Randi Olsen,Trine Lund,Dilip K. Prasad,Krishna Agarwal,Truls Myrmel,Åsa Birna Birgisdottir +12 more
TL;DR: In this paper , the authors visualized and assessed the level of mitophagy in H9c2 cardiomyoblasts at basal conditions and after OXPHOS induction by galactose adaptation.
Dissertation
Understanding the Role of the Co-Chaperone, Bcl-2 Associated Athanogene 5, in PINK1/parkin Dependent Mitophagy
TL;DR: In this paper, BAG5 was found to negatively affect PINK1 and parkin dependent mitophagy, as measured by a flow cytometry assay directly quantifying lysosomal engulfment of mitochondria.
Journal ArticleDOI
Research progress on iron uptake pathways and mechanisms of foodborne microorganisms and their application in the food sector.
TL;DR: In this paper , a review highlights the unresolved fate of siderophores in the iron uptake system and emphasizes further development of Siderophore-based substitutes for traditional drugs, new antibiotic-resistance drugs, and vaccines in the food and health sectors.
References
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