Loss of iron triggers PINK1/Parkin‐independent mitophagy
TLDR
A mitophagy pathway is identified and characterized, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.Abstract:
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.read more
Citations
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A Sensitive and Quantitative mKeima Assay for Mitophagy via FACS.
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Mitophagy and Neurodegeneration: Between the Knowns and the Unknowns
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Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
Jessica R. Ivy,Carter Rn,Jin-Feng Zhao,Charlotte Buckley,Helena Urquijo,Eva A. Rog-Zielinska,Emma Panting,Emma Panting,Lenka Hrabalkova,Cara Nicholson,Emma J Agnew,Matthew W. Kemp,Matthew W. Kemp,Matthew W. Kemp,Nicholas M. Morton,Sarah J. Stock,Sarah J. Stock,Caitlin S. Wyrwoll,Ian G. Ganley,Karen E. Chapman,Karen E. Chapman +20 more
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Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease
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Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy
Shun-ichi Yamashita,Masanao Kyuuma,Keiichi Inoue,Yuki Hata,Ryu Kawada,Masaki Yamabi,Yasuyuki Fujii,Junko Sakagami,Tomoyuki Fukuda,Kentaro Furukawa,Satoshi Tsukamoto,Tomotake Kanki +11 more
TL;DR: It is concluded that disuse enhances mitophagy activity and ROS production in atrophic skeletal muscles and suggests thatMitophagy is a potential therapeutic target for disuse‐induced muscle atrophy.
References
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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