Loss of iron triggers PINK1/Parkin‐independent mitophagy
TLDR
A mitophagy pathway is identified and characterized, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.Abstract:
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.read more
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FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors
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NCLX prevents cell death during adrenergic activation of the brown adipose tissue
Essam A. Assali,Essam A. Assali,Anthony E. Jones,Michaela Veliova,Mahmoud Taha,Nathanael Miller,Michael Shum,Marcus F. Oliveira,Guy Las,Marc Liesa,Israel Sekler,Orian S. Shirihai,Orian S. Shirihai +12 more
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Iron out, mitophagy in! A way to slow down hepatocellular carcinoma
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PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage
Olivia A. Lambourne,Léa P Wilhelm,Oliver M. Russell,Arwa M. Alghamdi,Carmine Varricchio,Emma Louise Lane,Ian G. Ganley,Arwyn Tomos Jones,Matthew S. Goldberg,Youcef Mehellou +9 more
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References
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