Loss of iron triggers PINK1/Parkin‐independent mitophagy
TLDR
A mitophagy pathway is identified and characterized, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.Abstract:
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.read more
Citations
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Journal ArticleDOI
Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
TL;DR: In this article , the authors identify several compounds that enhance the activity of Parkin in the presence of phospho-ubiquitin and act as positive allosteric modulators (PAMs).
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Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models
Christy B. M. Tulen,Yu Wang,Daan Beentjes,P. J. Jessen,Dennis K. Ninaber,Niki L. Reynaert,Frederik J. van Schooten,Antoon Opperhuizen,Pieter S. Hiemstra,Alexander Remels +9 more
TL;DR: Smoke exposure alters the regulation of mitochondrial metabolism in airway epithelial cells, but observed alterations may differ between various culture models used.
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Regulation of mitochondrial cargo-selective autophagy by posttranslational modifications.
Anna Lechado Terradas,Katharina Zittlau,Boris Macek,Milana Fraiberg,Zvulun Elazar,Philipp J. Kahle,Philipp J. Kahle +6 more
TL;DR: In this paper, a review of the mechanisms of mitophagy with an emphasis on posttranslational modifications that regulate various mitophagia pathways is presented, and the role of accessory factors regulating mitochondrial fission/fusion is discussed.
DissertationDOI
Parkinson's disease-associated proteins : studying their role in mitophagy with cellular and Drosophila models
TL;DR: The work performed during this thesis will set the basis for further studies to identify physiologically relevant Parkin substrates and to analyse mitophagy in vivo employing the mt-Keima flies.
Journal ArticleDOI
Targeting Mitophagy in Alzheimer's Disease.
Dona P.W. Jayatunga,Eugene Hone,Eugene Hone,Prashant Bharadwaj,Prashant Bharadwaj,Manohar L. Garg,Manohar L. Garg,Giuseppe Verdile,Giuseppe Verdile,Gilles J. Guillemin,Ralph N. Martins +10 more
TL;DR: The stimulation of mitophagy as an approach for attenuating neurodegeneration in AD is examined and the emerging concepts on Mitophagy, molecular regulation of theMitophagy process, current mitophitary detection methods, and mitophile dysfunction in AD are discussed.
References
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