Loss of iron triggers PINK1/Parkin‐independent mitophagy
TLDR
A mitophagy pathway is identified and characterized, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.Abstract:
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Iron chelation-induced mitophagy requires that cells undergo glycolysis, but does not require PINK1 stabilization or Parkin activation, and occurs in primary human fibroblasts as well as those isolated from a Parkinson's patient with Parkin mutations. Thus, we have identified and characterized a mitophagy pathway, the induction of which could prove beneficial as a potential therapy for several neurodegenerative diseases in which mitochondrial clearance is advantageous.read more
Citations
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Journal ArticleDOI
Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph.
Megan Cleland Harwig,Matheus P. Viana,John M. Egner,Jason J. Harwig,Michael E. Widlansky,Susanne M. Rafelski,R. Blake Hill +6 more
TL;DR: This prospective highlights the implementation of MitoGraph, an open-source image analysis platform for measuring mitochondrial morphology initially optimized for use with Saccharomyces cerevisiae, and successfully differentiated between distinct mitochondrial morphologies that ranged from entirely fragmented to hyper-elongated.
Journal ArticleDOI
Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases
Michael H. Irwin,Walter H. Moos,Walter H. Moos,Douglas V. Faller,Kosta Steliou,Carl A. Pinkert,Carl A. Pinkert +6 more
TL;DR: The potential of new therapies in this area extends to glaucoma and other ophthalmic disorders, migraine, Creutzfeldt-Jakob disease, post-traumatic stress disorder, systemic exertion intolerance disease, and chemotherapy-induced cognitive impairment as mentioned in this paper.
Journal ArticleDOI
BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains
Xiaoli Wu,Yanrong Zheng,Mengru Liu,Yue Li,Shijia Ma,Wei-dong Tang,Wenping Yan,Ming Cao,Wanqing Zheng,Lei Jiang,Jiaying Wu,Feng Han,Zheng-Hong Qin,Liang Fang,Weiwei Hu,Zhong Chen,Xiangnan Zhang +16 more
TL;DR: Carfilzomib, a drug for multiple myeloma therapy that inhibits proteasomes, reversed the BNIP3L degradation and restored mitophagy in ischemic brains and was abolished in bnip3l -/- mice.
Journal ArticleDOI
Ubiquitin and Receptor-Dependent Mitophagy Pathways and Their Implication in Neurodegeneration.
TL;DR: This review will discuss the known types of mitophagy observed in mammals, recent findings related to PINK1/Parkin-mediatedMitophagy (which is the most well-studied form of Mitophagy), discuss the implications of defective mitophile to neurodegenerative processes, and unanswered questions inspiring future research that would enhance the understanding of mitochondrial quality control.
Journal ArticleDOI
PINK1 signalling in cancer biology.
Ciara H. O'Flanagan,Cora O'Neill +1 more
TL;DR: The function of PINK1 in cancer cell biology is reviewed, with an emphasis on the mechanisms by which PPink1 interacts with PI3-kinase/Akt signalling, mitochondrial homeostasis, and the potential context-dependent pro- and anti-tumorigenic functions of Pink1.
References
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