Open AccessDOI
Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields
René König,Sara Lopez,Sara Lopez,René König,Nicolas Hallali,Yoann Lalatonne,Arnaud Hillion,Joana C. Antunes,Nizar Serhan,Nizar Serhan,Pascal Clerc,Pascal Clerc,Daniel Fourmy,Daniel Fourmy,Laurence Motte,Julian Carrey,Véronique Gigoux,Véronique Gigoux +17 more
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The article was published on 2022-01-01 and is currently open access. It has received 20 citations till now. The article focuses on the topics: Lysosome & Iron oxide nanoparticles.read more
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Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy
Thomas Vangijzegem,Valentin Lecomte,Indiana Ternad,Levy Van Leuven,Robert N. Muller,Dimitri Stanicki,Sophie Laurent +6 more
TL;DR: In this paper , the authors provide a comprehensive description of the fundamental aspects of superparamagnetic iron oxide nanoparticles (SPION) formulation and highlight various recent approaches regarding in vivo applications in the field of cancer therapy.
Journal ArticleDOI
Real-Time Observation and Analysis of Magnetomechanical Actuation of Magnetic Nanoparticles in Cells.
Arnaud Hillion,N. Hallali,Pascal Clerc,S.F. Lopez,Yoann Lalatonne,Camille Noûs,Laurence Motte,Véronique Gigoux,Julian Carrey +8 more
TL;DR: A miniaturized electromagnet fitted under a confocal microscope is used to observe in real time cells specifically targeted by superparamagnetic nanoparticles and exposed to a low-frequency rotating magnetic field, revealing that the lysosome membrane is permeabilized in only a few minutes after the start of magnetic field application.
Journal ArticleDOI
Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy
TL;DR: In this paper , a review of recent advances of multifunctional magnetic nanoparticles exhibiting unique characteristic for therapeutic applications are summarized, which utilize the "dynamic" motion, iron ion degradation, or imaging-guided targeting of the nanoparticles under diverse magnetic field modes.
Journal ArticleDOI
Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives
TL;DR: This review discusses the nature of the MNP-mediated mechanical forces and their order of magnitude, and shows some of the main applications of the magneto-mechanical approach in the control over the properties of biological systems.
Journal ArticleDOI
Mechanical stimuli-driven cancer therapeutics.
Jusung An,Hyunsik Hong,Miae Won,Hye Bog Rha,Qihang Ding,Nayeon Kang,Heemin Kang,Jong Seung Kim +7 more
TL;DR: In this article , the authors highlight the latest advances in mechanical cancer therapy to present a novel perspective on the fundamental principles of ultrasound and magnetic field-mediated mechanical forces, including compression, tension, shear force, and torque, that can be generated in a cellular microenvironment using mechanical stimuli-activated functional materials.
References
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging.
TL;DR: The T1 relaxivity can be improved (and the T2/T2* effect can be reduced) using small particles and T1-weighted imaging sequences, and superparamagnetic agents open up an important field for research in MR imaging.
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Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme
Klaus Maier-Hauff,Frank Ulrich,Dirk Nestler,Hendrik Niehoff,Peter Wust,Burghard Thiesen,Helmut Orawa,Volker Budach,Andreas Jordan +8 more
TL;DR: Thermotherapy using magnetic nanoparticles in conjunction with a reduced radiation dose is safe and effective and leads to longer OS-2 compared to conventional therapies in the treatment of recurrent glioblastoma.
Journal ArticleDOI
Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
Rosa F. Hwang,Todd Moore,Thiruvengadam Arumugam,Vijaya Ramachandran,Keith D. Amos,Armando Rivera,Baoan Ji,Douglas B. Evans,Craig D. Logsdon +8 more
TL;DR: Data indicate that stellate cells have an important role in supporting and promoting pancreatic cancer, and the presence of HPSCs in tumors increases the growth and metastasis of these cells.
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Identification, Culture, and Characterization of Pancreatic Stellate Cells in Rats and Humans
Max G. Bachem,Erik Schneider,Hans Groß,Hans Weidenbach,Roland M. Schmid,Andre Menke,Marco Siech,Hans G. Beger,Adolf Grünert,Guido Adler +9 more
TL;DR: The identification of retinoid-containing pancreatic stellate cells (PSCs) in rat and human pancreas are described, and morphological and biochemical similarities to hepatic stellates cells are shown, suggesting that PSCs participate in the development of Pancreas fibrosis.