Journal ArticleDOI
Maternal Immune Activation by Poly I:C as a preclinical Model for Neurodevelopmental Disorders: A focus on Autism and Schizophrenia.
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TLDR
Empirical evidence for the effects of maternal infection and immune activation, as well as major findings in different poly I:C MIA models with a focus on polyI:C exposure timing, behavioural and molecular changes in the offspring, are reviewed.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2020-06-01. It has received 92 citations till now. The article focuses on the topics: Autism & Autism spectrum disorder.read more
Citations
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COVID-19 in pregnancy: implications for fetal brain development
TL;DR: Al-Haddad et al. as mentioned in this paper reviewed evidence that SARS-CoV-2 and other viral infections during pregnancy can result in maternal, placental, and fetal immune activation, and ultimately in offspring neurodevelopmental morbidity.
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What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders
TL;DR: The past decade's literature is reviewed and a critical commentary on the involvement of immunological mechanisms in normal brain development, as well as its role in the pathophysiology of Tourette syndrome, other Chronic tic disorders, and related neuropsychiatric disorders including Obsessive-compulsive disorder (OCD) and Attention deficit hyperactivity disorder (ADHD).
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Maternal Immune Activation and the Development of Dopaminergic Neurotransmission of the Offspring: Relevance for Schizophrenia and Other Psychoses.
TL;DR: Evidence from animal models of maternal immune activation (MIA) and the behavioral and molecular alterations relevant for the function of the DAergic system are summarized, and the involvement of maternal cytokines in mediating the effects of MIA on the fetal brain, leading to the long-lasting effects on the offspring is discussed.
Journal ArticleDOI
Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study.
Elisa Guma,Elisa Guma,Pedro Bordignon,Gabriel A. Devenyi,Daniel Gallino,Chloe Anastassiadis,Vedrana Cvetkovska,Amadou Barry,Emily Snook,Jürgen Germann,Celia M. T. Greenwood,Bratislav Misic,Rosemary C. Bagot,M. Mallar Chakravarty +13 more
TL;DR: For example, the authors found that early MIA exposure was associated with accelerated brain volume increases in adolescence/early adulthood that normalized in later adulthood in the striatum, hippocampus, and cingulate cortex.
Journal ArticleDOI
Advantages and Limitations of Animal Schizophrenia Models
Magdalena Bialon,Agnieszka Wąsik +1 more
TL;DR: Animal models of schizophrenia are essential to gain a better understanding of the disease etiopathology and mechanism of action of currently used antipsychotic drugs and help in the search for new and more effective therapies.
References
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Journal ArticleDOI
Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
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Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
Taro Kawai,Shizuo Akira +1 more
TL;DR: The role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition is focused on.
Journal ArticleDOI
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Elaine Y. Hsiao,Sara Mcbride,Sophia Hsien,Gil Sharon,Embriette R. Hyde,Tyler McCue,Julian A. Codelli,Janet Chow,Sarah E. Reisman,Joseph F. Petrosino,Paul H. Patterson,Sarkis K. Mazmanian +11 more
TL;DR: A gut-microbiome-brain connection in a mouse model of ASD is supported and a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders is identified.
Journal ArticleDOI
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Stephen E. P. Smith,Jennifer S. Li,Jennifer S. Li,Krassimira A. Garbett,Karoly Mirnics,Paul H. Patterson +5 more
TL;DR: It is shown that the cytokine interleukin-6 (IL-6) is critical for mediating the behavioral and transcriptional changes in the offspring and should be identified as a key intermediary in the molecular dissection of the pathways whereby MIA alters fetal brain development.
Journal ArticleDOI
The environment and schizophrenia
TL;DR: Although heritability is often emphasized, onset is associated with environmental factors such as early life adversity, growing up in an urban environment, minority group position and cannabis use, suggesting that exposure may have an impact on the developing ‘social’ brain during sensitive periods.
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Maternal immune activation: Implications for neuropsychiatric disorders
Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.
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