Journal ArticleDOI
Measurement of Viscoelastic Properties of Polyacrylamide-Based Tissue-Mimicking Phantoms for Ultrasound Elastography Applications
TLDR
Polyacrylamide gel based tissue-mimicking phantoms have been developed to experimentally study the role of viscoelastic properties inPhantoms and indicate that stiffer samples exhibit large variations in the storage modulus when the precompression levels are altered.Abstract:
Many ailments and/or malfunctions of the body have been observed to change the viscous behavior and elastic properties of biological soft tissues. The technique of elastography has evolved to image such properties. The clinical evidence gathered during studies involving elastography to identify cancerous lesions is very promising. However, the quantification of the resolution and specificity of elastography is best achieved under a controlled study using tissue-mimicking phantoms. One challenge is to reproduce viscoelastic behavior in phantoms as observed in biological tissues. In this paper, polyacrylamide gel based tissue-mimicking phantoms have been developed to experimentally study the role of viscoelastic properties in a controlled manner. To measure the Young's modulus, the phantoms were subjected to linear loading, and the stress-strain relationship is deduced therefrom. It is seen that the phantoms show hysteresis behavior. The viscoelastic properties of these phantoms were measured by subjecting the samples to cyclic loading. Normal forces during this process of loading were also measured as a measure of sample elasticity. To emulate the normal and pathological lesions, samples were prepared with varying concentration of monomer and studied. Three models, namely, Maxwell, Kelvin-Voigt (KV), and Kelvin-Voigt fractional derivative (KVFD), were chosen to fit the experimental data. Of these, the KVFD model was found to be best fitting for the experimental data obtained. Results indicate that stiffer samples exhibit large variations in the storage modulus when the precompression levels are altered.read more
Citations
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Journal ArticleDOI
Towards a consensus on rheological models for shear waves in soft tissues
TL;DR: This paper argued that the long history of biomechanics, including the concept of the extended relaxation spectrum, along with data collected from viscoelastic soft tissues over an extended range of times and frequencies, and the theoretical framework of multiple relaxation models which model the multi-scale nature of physical tissues, all lead to the conclusion that fractional derivative models represent the most succinct and meaningful models of soft tissue visco-elastic behavior.
Proceedings ArticleDOI
Development of high fidelity liver and kidney phantom organs for use with robotic surgical systems
TL;DR: A manufacturing process and methodology to create inexpensive, anatomically accurate kidney and liver phantom organs from gelatin gel with Young's moduli and ultrasound (US) attenuation coefficients matched to those of a porcine kidneys and liver are presented.
Journal ArticleDOI
A 3-D Nonhomogeneous FE Model of Human Fingertip Based on MRI Measurements
TL;DR: It is found that the Voigt model can simulate the force behaviors of a fingertip phantom but has difficulty to reproduce the force relaxation behavior of a human fingertip, so a parallel five-parameter physical model is introduced to solve this problem.
Journal ArticleDOI
Cavitation distribution within large phantom vessel and mechanical damage formed on surrounding vessel wall.
TL;DR: The Sonoluminescence method, mechanical damage observation and high-speed camera were used in this study to investigate the combination effect of ultrasound contrast agents (UCAs) and continuous FU in large phantom vessels without consideration of thermal effect and it is suggested that these findings need to be considered in the large vessel therapy and UCAs usage.
Journal ArticleDOI
Determination of Dynamic Material Properties of Silicone Rubber Using One-Point Measurements and Finite Element Simulations
TL;DR: The dynamic Young's modulus, Poisson's ratio, and the damping factor of silicone rubber are determined from a laser triangulation measurement of the top surface motion of a flat cylindrical sample excited by a shaker to provide a precise description of vocal fold models.
References
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Book
Viscoelastic properties of polymers
TL;DR: In this article, the authors describe the nature of Viscoelastic behavior of polymeric systems and approximate relations among the linear Viscoels and approximate interrelations among the Viscelastic Functions.
Journal ArticleDOI
Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues
TL;DR: Initial results of several phantom and excised animal tissue experiments are reported which demonstrate the ability of this technique to quantitatively image strain and elastic modulus distributions with good resolution, sensitivity and with diminished speckle.
MonographDOI
Mechanical Behavior of Materials
TL;DR: A balanced mechanics-materials approach and coverage of the latest developments in biomaterials and electronic materials, the new edition of this popular text is the most thorough and modern book available for upper-level undergraduate courses on the mechanical behavior of materials as discussed by the authors.
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An Introduction To Rheology
TL;DR: In this article, the authors discuss the importance of non-linearity solids and liquids rheology is a difficult subject for rheological research, and present some demonstrations of high extensional viscosity behaviour.