Mechanisms and function of substrate recruitment by F-box proteins
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TLDR
The evolution of substrate recruitment by F-box proteins, the dysregulation of substrates in disease and potential avenues for F- box protein-directed disease therapies are focused on.Abstract:
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes The dysregulation of SCF complexes and their substrates contributes to multiple pathologies In the 14 years since the identification and annotation of the F-box protein family, the continued identification and characterization of novel substrates has greatly expanded our knowledge of the regulation of substrate targeting and the roles of F-box proteins in biological processes Here, we focus on the evolution of our understanding of substrate recruitment by F-box proteins, the dysregulation of substrate recruitment in disease and potential avenues for F-box protein-directed disease therapiesread more
Citations
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A Cellular Mechanism to Detect and Alleviate Reductive Stress
Andrew G. Manford,Fernando Rodríguez-Pérez,Karen Y. Shih,Zhuo Shi,Charles A. Berdan,Mangyu Choe,Denis V. Titov,Daniel K. Nomura,Michael Rape,Michael Rape +9 more
TL;DR: The reductive stress response is built around a ubiquitin-dependent rheostat that tunes mitochondrial activity to redox needs and implicates metabolic control in coordination of stress and developmental signaling.
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FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development
Yue Jin,Yue Jin,Anitha K. Shenoy,Samuel N. Doernberg,Hao Chen,Huacheng Luo,Huangxuan Shen,Tong Lin,Miriam Tarrash,Qingsong Cai,Xin Hu,Ryan Fiske,Ting Chen,Lizi Wu,Kamal A. Mohammed,Veerle Rottiers,Siu Sylvia Lee,Jianrong Lu +17 more
TL;DR: The results suggest that the FBXO11-Snail regulatory axis is evolutionarily conserved and critically governs carcinoma progression and mammalian epidermal development.
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Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
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F-box protein interactions with the hallmark pathways in cancer.
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Molecular networks regulating cell division during Arabidopsis leaf growth.
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TL;DR: In this article, the authors analyzed whole-exome sequencing data from 74 tumor-normal pairs and found that at least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6, and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis.
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