Mechanisms and function of substrate recruitment by F-box proteins
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TLDR
The evolution of substrate recruitment by F-box proteins, the dysregulation of substrates in disease and potential avenues for F- box protein-directed disease therapies are focused on.Abstract:
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes The dysregulation of SCF complexes and their substrates contributes to multiple pathologies In the 14 years since the identification and annotation of the F-box protein family, the continued identification and characterization of novel substrates has greatly expanded our knowledge of the regulation of substrate targeting and the roles of F-box proteins in biological processes Here, we focus on the evolution of our understanding of substrate recruitment by F-box proteins, the dysregulation of substrate recruitment in disease and potential avenues for F-box protein-directed disease therapiesread more
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FBXL4 deficiency increases mitochondrial removal by autophagy.
David Alsina,David Alsina,Oleksandr Lytovchenko,Oleksandr Lytovchenko,Aleksandra Schab,Ilian Atanassov,Florian A. Schober,Florian A. Schober,Min Jiang,Camilla Koolmeister,Camilla Koolmeister,Anna Wedell,Anna Wedell,Robert W. Taylor,Anna Wredenberg,Anna Wredenberg,Anna Wredenberg,Nils-Göran Larsson,Nils-Göran Larsson,Nils-Göran Larsson +19 more
TL;DR: The results presented here show that FBXL4 prevents mitochondrial removal via autophagy and that loss ofFBXL4 leads to decreased mitochondrial content and mitochondrial disease.
Journal ArticleDOI
Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.
Tomomi Nakajima,Kyoko Kitagawa,Tatsuya Ohhata,Satoshi Sakai,Chiharu Uchida,Kiyoshi Shibata,Naoko Minegishi,Kanae Yumimoto,Keiichi I. Nakayama,Kazuma Masumoto,Fuminori Katou,Hiroyuki Niida,Masatoshi Kitagawa +12 more
TL;DR: F-box/WD repeat-containing protein 7 (Fbw7/Fbxw7), a component of Skp1, Cullin 1, F-box-containing complex (SCF)-type E3 ligase, is a bona fide E3 ubiquitin ligase for GATA2 in vivo, indicating that GATA-binding protein 2 is a novel target for Fbw 7.
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Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinson's disease (PD).
TL;DR: The pathological mechanisms concerning FBXO7-relevant protein aggregation, mitochondria impairment, reactive oxygen species (ROS) generation and mitophagy modulation in PARK15 pathogenesis are highlighted and discussed in the current review.
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The Role of the Anaphase-Promoting Complex/Cyclosome in Plant Growth
TL;DR: Current understanding of the APC/C controlling plant growth is discussed, including its role in cellular differentiation, vascular development, shoot branching, female and male gametophyte development and embryogenesis.
Journal ArticleDOI
Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
TL;DR: Targeting these F-box proteins involved in drug resistance might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers.
References
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The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
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TL;DR: In this article, the authors analyzed whole-exome sequencing data from 74 tumor-normal pairs and found that at least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6, and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis.
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