Mechanisms and function of substrate recruitment by F-box proteins
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TLDR
The evolution of substrate recruitment by F-box proteins, the dysregulation of substrates in disease and potential avenues for F- box protein-directed disease therapies are focused on.Abstract:
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes The dysregulation of SCF complexes and their substrates contributes to multiple pathologies In the 14 years since the identification and annotation of the F-box protein family, the continued identification and characterization of novel substrates has greatly expanded our knowledge of the regulation of substrate targeting and the roles of F-box proteins in biological processes Here, we focus on the evolution of our understanding of substrate recruitment by F-box proteins, the dysregulation of substrate recruitment in disease and potential avenues for F-box protein-directed disease therapiesread more
Citations
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Journal ArticleDOI
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.
Vishnu Mohanan,Vishnu Mohanan,Toru Nakata,Toru Nakata,A. Nicole Desch,A. Nicole Desch,Chloé Lévesque,Angela C. Boroughs,Gaelen Guzman,Zhifang Cao,Elizabeth A. Creasey,Junmei Yao,Gabrielle Boucher,Guy Charron,Atul K. Bhan,Monica Schenone,Steven A. Carr,Hans Christian Reinecker,Mark J. Daly,Mark J. Daly,John D. Rioux,John D. Rioux,Kara G. Lassen,Kara G. Lassen,Ramnik J. Xavier +24 more
TL;DR: It is demonstrated that C1orf106 regulates adherens junction stability by regulating the degradation of cytohesin-1, a guanine nucleotide exchange factor that controls activation of ARF6.
Journal ArticleDOI
Light-Dependent Degradation of PIF3 by SCFEBF1/2 Promotes a Photomorphogenic Response in Arabidopsis
TL;DR: It is reported that, in response to light activation of phytochrome photoreceptors, EIN3-BINDing F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induced phosphorylation of Pif3.
Journal ArticleDOI
Fbw7 dimerization determines the specificity and robustness of substrate degradation
Markus Welcker,Elizabeth A. Larimore,Elizabeth A. Larimore,Jherek Swanger,Maria T. Bengoechea-Alonso,Jonathan E. Grim,Johan Ericsson,Ning Zheng,Ning Zheng,Bruce E. Clurman +9 more
TL;DR: Critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation are shown and an unanticipated complexity in substrate degradation is revealed.
Journal ArticleDOI
Recent advances in SCF ubiquitin ligase complex: Clinical implications.
TL;DR: This article describes how F-box proteins including but not restricted to well-established Fbw7, Skp2 and β-TRCP, are involved in tumorigenesis and suggests that targeting F-boxes could possibly open new avenues for the treatment and prevention of human cancers.
Journal ArticleDOI
Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins
TL;DR: It is postulate that a few extraordinary FBPs act as platforms that seamlessly segue their canonical and non-canonical functions to integrate different cellular pathways and link their regulation.
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