Journal ArticleDOI
Mechanisms for the control of gene activity during development
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TLDR
(4) Somatic cells of Drosophila (5) Imprinting and germ line transmission (6) Maize transposable elements (7) Modification of integrated DNA in fungi (8) Cancer and ageing (9) ConclusionsAbstract:
(4) Somatic cells of Drosophila (5) Imprinting and germ line transmission (6) Maize transposable elements . . . . . . . . . . . (7) Modification of integrated DNA in fungi (8) Cancer and ageing . . . . . . . . . . . . . V . Conclusions . . . . . . . . . . . . . . . ( I ) General significance of DNA methylation (2) Major components of development . . . . . . . . . . VI . Acknowledgements . . . . . . . . . . . . . . . . . . . . . . .read more
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The Role of Oxidative Stress in Carcinogenesis
TL;DR: This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species.
Journal ArticleDOI
Epigenetic transgenerational actions of environmental factors in disease etiology
TL;DR: An overview of the epigenetics and biology of how environmental factors can promote transgenerational phenotypes and disease is provided.
Journal ArticleDOI
Association of Arsenic-Induced Malignant Transformation with DNA Hypomethylation and Aberrant Gene Expression
Christopher Q. Zhao,Matthew R. Young,Bhalchandra A. Diwan,Timothy P. Coogan,Michael P. Waalkes +4 more
TL;DR: Results indicate arsenic can act as a carcinogen by inducing DNA hypomethylation, which in turn facilitates aberrant gene expression, and they constitute a tenable theory of mechanism in arsenic carcinogenesis.
Journal ArticleDOI
Mapping Human Epigenomes
TL;DR: This review discusses the current epigenome mapping toolkit and utilities, and focuses particularly on mapping of DNA methylation, chromatin modification state, and chromatin structures, and emphasize the use of epigenome maps to delineate human gene regulatory sequences and developmental programs.
Journal ArticleDOI
The Changing Concept of Epigenetics
Eva Jablonka,Marion J. Lamb +1 more
TL;DR: Recognizing that there are epigenetic inheritance systems through which non‐DNA variations can be transmitted in cell and organismal lineages broadens the concept of heredity and challenges the widely accepted gene‐centered neo‐Darwinian version of Darwinism.
References
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Journal ArticleDOI
The Chemical Basis of Morphogenesis
TL;DR: In this article, it is suggested that a system of chemical substances, called morphogens, reacting together and diffusing through a tissue, is adequate to account for the main phenomena of morphogenesis.
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The Chemical Basis of Morphogenesis
TL;DR: A possible mechanism by which the genes of a zygote may determine the anatomical structure of the resulting organism is discussed, suggesting that certain well-known physical laws are sufficient to account for many of the facts.
Journal ArticleDOI
The embryonic cell lineage of the nematode Caenorhabditis elegans.
TL;DR: It is concluded that the cell lineage itself, complex as it is, plays an important role in determining cell fate and is demonstrated to demonstrate substantial cell autonomy in at least some sections of embryogenesis.
Journal ArticleDOI
Somatic generation of antibody diversity
TL;DR: In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome which are assembled by recombination which leads to the formation of a complete gene.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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