Medical marijuana for cancer.
TLDR
A review of the literature regarding the medical use of marijuana and these cannabinoid pharmaceuticals (with emphasis on indications relevant to oncology), as well as available information regarding adverse effects of marijuana use is presented in this article.Abstract:
Answer questions and earn CME/CNE Marijuana has been used for centuries, and interest in its medicinal properties has been increasing in recent years. Investigations into these medicinal properties has led to the development of cannabinoid pharmaceuticals such as dronabinol, nabilone, and nabiximols. Dronabinol is best studied in the treatment of nausea secondary to cancer chemotherapy and anorexia associated with weight loss in patients with acquired immune deficiency syndrome, and is approved by the US Food and Drug Administration for those indications. Nabilone has been best studied for the treatment of nausea secondary to cancer chemotherapy. There are also limited studies of these drugs for other conditions. Nabiximols is only available in the United States through clinical trials, but is used in Canada and the United Kingdom for the treatment of spasticity secondary to multiple sclerosis and pain. Studies of marijuana have concentrated on nausea, appetite, and pain. This article will review the literature regarding the medical use of marijuana and these cannabinoid pharmaceuticals (with emphasis on indications relevant to oncology), as well as available information regarding adverse effects of marijuana use.read more
Citations
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Journal ArticleDOI
Management of Chronic Pain in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
Judith A. Paice,Russell K. Portenoy,Christina Lacchetti,Toby C. Campbell,Andrea L. Cheville,Marc L. Citron,Louis S. Constine,Andrea Cooper,Paul Glare,F.J. Keefe,Lakshmi Koyyalagunta,Michael H. Levy,Christine Miaskowski,Shirley Otis-Green,Paul A. Sloan,Eduardo Bruera +15 more
TL;DR: An ASCO-convened expert panel conducted a systematic literature search of studies investigating chronic pain management in cancer survivors to provide evidence-based guidance on the optimum management of chronic pain in adult cancer survivors.
Journal ArticleDOI
Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use
Steven A. Pergam,Maresa C. Woodfield,Christine M. Lee,Guang‐Shing Cheng,Kelsey Baker,Sara Marquis,Jesse R. Fann +6 more
TL;DR: This study was designed to determine the prevalence and methods of use among cancer patients, the perceived benefits, and the sources of information in a state with legalized cannabis.
Book
Handbook of Cancer Survivorship
TL;DR: The Burden of Cancer Survivorship, Management of Chemotherapy-Related Cognitive Dysfunction, and Psychological Distress, Depression, and Anxiety are examined.
Journal ArticleDOI
The current state and future perspectives of cannabinoids in cancer biology.
TL;DR: This review presents an actual state of knowledge regarding molecular mechanisms of cannabinoids’ anticancer action, but discusses also aspects that are still not fully understood such as the role of the endocannabinoid system in a carcinogenesis, the impact of cannabinoids on the immune system in the context of cancer development, or the cases of a stimulation of cancer cells’ proliferation by cannabinoids.
Journal ArticleDOI
Therapeutic potential of cannabis-related drugs.
TL;DR: The dual nature of Cannabis and cannabinoids is considered, which arises from the potential and actuality of cannabinoids in the laboratory and clinic and the 'abuse' of Cannabis outside the clinic.
References
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The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
TL;DR: This review focuses on the manner with which three of these compounds, (−)‐trans‐Δ 9‐tetrahydrocannabinol (Δ9‐THC), (−]‐cannabidiol (CBD) and (−)-trans‐ Δ9‐TetrahYDrocannabivarin (Γ‐THCV), interact with cannabinoid CB1 and CB2 receptors.
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Pharmacokinetics and Pharmacodynamics of Cannabinoids
TL;DR: Properties of cannabis that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, sedation, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and induction of apoptosis in cancer cells.
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Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis
TL;DR: Acute cannabis consumption is associated with an increased risk of a motor vehicle crash, especially for fatal collisions, and could be used as the basis for campaigns against drug impaired driving, developing regional or national policies to control acute drug use while driving, and raising public awareness.
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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.
Sagnik Bhattacharyya,Paul D. Morrison,Paolo Fusar-Poli,Paolo Fusar-Poli,Rocio Martin-Santos,Stefan Borgwardt,Stefan Borgwardt,Toby T. Winton-Brown,Chiara Nosarti,Colin M O' Carroll,Marc L. Seal,Paul Allen,Mitul A. Mehta,James M. Stone,Nigel Tunstall,Vincent Giampietro,Shitij Kapur,Robin M. Murray,Antonio Waldo Zuardi,José Alexandre de Souza Crippa,Zerrin Atakan,Philip McGuire +21 more
TL;DR: Functional magnetic resonance imaging in healthy volunteers found that Δ-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Δ- 9- THC.
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Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
TL;DR: CBM was generally well tolerated, although more patients on CBM than placebo reported dizziness, dry mouth, and somnolence, and Cognitive side effects were limited to long-term memory storage.