Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement
TLDR
The molecular mechanisms underlying MSC homing are reviewed, based on a multistep model involving initial tethering by selectins, activation by cytokines, arrest by integrins, diapedesis or transmigration using matrix remodelers, and extravascular migration toward chemokine gradients.About:
This article is published in iScience.The article was published on 2019-05-31 and is currently open access. It has received 271 citations till now. The article focuses on the topics: Homing (hematopoietic) & Regenerative medicine.read more
Citations
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Shattering barriers toward clinically meaningful MSC therapies.
Oren Levy,Rui Kuai,Rui Kuai,Erika M. J. Siren,Deepak Bhere,Yuka Milton,Nabeel Nissar,Michael De Biasio,Martina Heinelt,Brock Reeve,Reza Abdi,Meshael Alturki,Mohanad Fallatah,Abdulaziz Almalik,Ali H. Alhasan,Khalid Shah,Khalid Shah,Jeffrey M. Karp +17 more
TL;DR: The major clinical challenges with MSC therapies, the details of these challenges, and the potential bioengineering approaches that leverage the unique biology of MSCs to overcome the challenges and achieve more potent and versatile therapies are discussed.
Journal ArticleDOI
Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress.
TL;DR: The progress in the study on the mechanisms underlying the immunomodulatory and regenerative effects of MSCs is reviewed; the medical translation of MCCs is updated, focusing on the registration trials leading to regulatory approvals; and how to improve therapeutic efficacy and safety of M SC applications for future is discussed.
Journal ArticleDOI
Advances in Analysis of Biodistribution of Exosomes by Molecular Imaging
Yong Weon Yi,Jun Ho Lee,Sang-Yeob Kim,Sang-Yeob Kim,Chan-Gi Pack,Chan-Gi Pack,Dae Hyun Ha,Sang Rae Park,Jinkwon Youn,Byong Seung Cho +9 more
TL;DR: The current trends and the advantages and disadvantages of the methods used to determine the biodistribution of exosomes by molecular imaging are examined and 29 publications are reviewed to compare the methods employed to isolate, analyze, and label exosome as well as to determine.
Journal ArticleDOI
Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders.
Alexander Markov,Lakshmi Thangavelu,Surendar Aravindhan,Angelina Olegovna Zekiy,Mostafa Jarahian,Max Stanley Chartrand,Yashwant Pathak,Faroogh Marofi,Somayeh Shamlou,Ali Hassanzadeh +9 more
TL;DR: In this paper, mesenchymal stem/stromal cells (MSCs) and their potential biomedical applications have received much attention from the global scientific community in an increasing manner, including self-renewability, multipotency, and easy accessibility are just one side of the coin; another side is their huge secretome which is comprised of hundreds of mediators, cytokines and signaling molecules and can effectively modulate the inflammatory responses and control the infiltration process that finally leads to a regulated tissue repair/healing or regeneration process.
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Stem cell homing: From physiology to therapeutics.
TL;DR: In this review, the process of HSPC and MSC homing is examined, as are methods to enhance this process.
References
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Human Adipose Tissue Is a Source of Multipotent Stem Cells
Patricia A. Zuk,Min Zhu,Peter Ashjian,Daniel A. De Ugarte,Jerry I. Huang,Hiroshi Mizuno,Zeni Alfonso,John K. Fraser,Prosper Benhaim,Marc H. Hedrick +9 more
TL;DR: To confirm whether adipose tissue contains stem cells, the PLA population and multiple clonal isolates were analyzed using several molecular and biochemical approaches and PLA cells exhibited unique characteristics distinct from those seen in MSCs, including differences in CD marker profile and gene expression.
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Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo
TL;DR: Postnatal human DPSCs are isolated that have the ability to form a dentin/pulp-like complex and are compared with human bone marrow stromal cells, known precursors of osteoblasts.
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A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more
TL;DR: Blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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Mesenchymal Stem Cells
TL;DR: The bone marrow contains multipotent MSC, which can be easily isolated and cultured in vitro, and the possibility of their clinical use in cell and gene therapy is analyzed.
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