Journal ArticleDOI
Metabolic engineering of flavonoids in plants and microorganisms
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TLDR
This work summarizes some of the recent metabolic engineering strategies in plants and microorganisms, with a focus on applications of metabolic flux analysis and is confident that these engineering approaches will lead to successful industrial flavonoid production in the near future.Abstract:
Over 9,000 flavonoid compounds have been found in various plants, comprising one of the largest families of natural products. Flavonoids are an essential factor in plant interactions with the environment, often serving as the first line of defense against UV irradiation and pathogen attacks. Flavonoids are also major nutritional compounds in foods and beverages, with demonstrated health benefits. Some flavonoids are potent antioxidants, and specific flavonoid compounds are beneficial in many physiological and pharmacological processes. Therefore, engineering of flavonoid biosynthesis in plants or in microorganisms has significant scientific and economical importance. Construction of biosynthetic pathways in heterologous systems offers promising results for large-scale flavonoid production by fermentation or bioconversion. Genomics and metabolomics now offer unprecedented tools for detailed understanding of the engineered transgenic organism and for developing novel technologies to further increase flavonoid production yields. We summarize some of the recent metabolic engineering strategies in plants and microorganisms, with a focus on applications of metabolic flux analysis. We are confident that these engineering approaches will lead to successful industrial flavonoid production in the near future.read more
Citations
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Journal ArticleDOI
Chemistry and Biological Activities of Flavonoids: An Overview
Shashank Kumar,Abhay K. Pandey +1 more
TL;DR: The structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production are highlighted.
Journal ArticleDOI
The re-emergence of natural products for drug discovery in the genomics era
TL;DR: This work reviews strategies for natural product screening that harness the recent technical advances that have reduced technical barriers and assess the use of genomic and metabolomic approaches to augment traditional methods of studying natural products.
Journal ArticleDOI
Discovery and resupply of pharmacologically active plant-derived natural products: A review.
Atanas G. Atanasov,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Thomas Linder,Christoph Wawrosch,Pavel Uhrin,Veronika Temml,Limei Wang,Stefan Schwaiger,Elke H. Heiss,Judith M. Rollinger,Judith M. Rollinger,Daniela Schuster,Johannes M. Breuss,Valery N. Bochkov,Marko D. Mihovilovic,Brigitte Kopp,Rudolf Bauer,Verena M. Dirsch,Hermann Stuppner +19 more
TL;DR: While the intrinsic complexity of natural product-based drug discovery necessitates highly integrated interdisciplinary approaches, the reviewed scientific developments, recent technological advances, and research trends clearly indicate that natural products will be among the most important sources of new drugs in the future.
Journal ArticleDOI
Bioactive flavonoids in medicinal plants: Structure, activity and biological fate.
TL;DR: A review of relationships between structure, activity, and pharmacokinetics of bioactive flavonoids is presented in this article, which attempts to bring some order into relationship between structure and activity.
Journal ArticleDOI
The role of flavonoids in root–rhizosphere signalling: opportunities and challenges for improving plant–microbe interactions
Samira Hassan,Ulrike Mathesius +1 more
TL;DR: The manipulation of the flavonoid pathway to synthesize specifically certain products has been suggested as an avenue to improve root-rhizosphere interactions and the overlapping functions of many flavonoids as stimulators of functions in one organism and inhibitors of another suggests caution in attempts to manipulate flavonoidal rhizosphere signals.
References
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Journal ArticleDOI
Flavonoid Biosynthesis. A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology
TL;DR: The role of flavonoids as the major red, blue, and purple pigments in plants has gained these secondary products a great deal of attention over the years.
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Flavonoids: a review of probable mechanisms of action and potential applications
Robert J. Nijveldt,Els Van Nood,Danny E. C. van Hoorn,Petra G. Boelens,Klaske van Norren,Paul A. M. van Leeuwen +5 more
TL;DR: The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances.
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Flavonoids and isoflavonoids – a gold mine for metabolic engineering
TL;DR: In this article, activation tagging was used for the discovery of uncharacterized structural and regulatory genes of the flavonoid biosynthesis pathway in plants and for the identification of new enzymatic specificities based on emerging protein structure data.
Journal ArticleDOI
Structure and function of enzymes involved in the biosynthesis of phenylpropanoids
TL;DR: Atomic resolution insights into the architecture and mechanistic underpinnings of phenylpropanoid metabolizing enzymes contribute to the understanding of the emergence and on-going evolution of specialized phenyl Propanoid products, and underscore the molecular basis of metabolic biodiversity at the chemical level.
Journal ArticleDOI
Flavonoid Accumulation in Arabidopsis Repressed in Lignin Synthesis Affects Auxin Transport and Plant Growth
Sébastien Besseau,Laurent Hoffmann,Pierrette Geoffroy,Catherine Lapierre,Brigitte Pollet,Michel Legrand +5 more
TL;DR: Data demonstrate that the reduced size phenotype of HCT-silenced plants is not due to the alteration of lignin synthesis but to flavonoid accumulation, which is shown to be controlled by light and to depend on chalcone synthase expression.