Journal ArticleDOI
Metastatic sites and survival in lung cancer
Matias Riihimäki,Matias Riihimäki,Akseli Hemminki,Mahdi Fallah,Hauke Thomsen,Kristina Sundquist,Jan Sundquist,Jan Sundquist,Kari Hemminki,Kari Hemminki +9 more
TLDR
A novel population-based approach to identify metastases from both death certificates and national inpatient data to describe metastatic pathways in lung cancer patients found liver metastases conferred the worst prognosis, especially for large cell histology.About:
This article is published in Lung Cancer.The article was published on 2014-10-01. It has received 530 citations till now. The article focuses on the topics: Bone metastasis & CA15-3.read more
Citations
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Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial.
Martin Reck,Tony Mok,Makoto Nishio,Robert M. Jotte,Federico Cappuzzo,Francisco Orlandi,Daniil Stroyakovskiy,Naoyuki Nogami,Delvys Rodriguez-Abreu,Denis Moro-Sibilot,Christian A. Thomas,Fabrice Barlesi,Gene Grant Finley,Anthony Lee,Shelley Coleman,Yu Deng,Marcin Kowanetz,Geetha Shankar,W. Lin,Mark A. Socinski,Tony Sk Mok +20 more
TL;DR: Improved overall survival with ABCP versus BCP was observed in patients with sensitising EGFR mutations, and overall survival in the intention-to-treat population, including EGFR-positive patients and patients with baseline liver metastases.
Journal ArticleDOI
Patterns of metastasis in colon and rectal cancer
TL;DR: Assessment of metastatic spread in colon and rectal cancers using a population based approach revealed Thoracic metastases are almost as common as liver metastases in rectal cancer patients with a low stage at diagnosis and should help clinicians to identify patients in need for extra surveillance.
Journal ArticleDOI
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.
Nayoung K.D. Kim,Nayoung K.D. Kim,Nayoung K.D. Kim,Hong Kwan Kim,Kyungjong Lee,Yourae Hong,Yourae Hong,Jong Ho Cho,Jung Won Choi,Jung-Il Lee,Yeon-Lim Suh,Bo Mi Ku,Hye Hyeon Eum,Hye Hyeon Eum,Hye Hyeon Eum,Soyean Choi,Yoon-La Choi,Yoon-La Choi,Je-Gun Joung,Woong-Yang Park,Woong-Yang Park,Hyun Ae Jung,Jong-Mu Sun,Se-Hoon Lee,Jin Seok Ahn,Keunchil Park,Myung-Ju Ahn,Hae-Ock Lee +27 more
TL;DR: The authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics to improve understanding of molecular and cellular dynamics in metastatic lung cancer.
Journal ArticleDOI
Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer.
Stephen J Bagley,Shawn Kothari,Charu Aggarwal,Joshua Bauml,Evan W. Alley,Tracey L. Evans,John A. Kosteva,Christine Ciunci,Peter Gabriel,Jeffrey C. Thompson,Susan Stonehouse-Lee,Victoria Sherry,Elizabeth Gilbert,Beth Eaby-Sandy,Faith Mutale,Gloria Dilullo,Roger B. Cohen,Anil Vachani,Corey J. Langer +18 more
TL;DR: In a cohort of patients with NSCLC treated with nivolumab in routine practice, pretreatment NLR≥5 was associated with inferior outcomes, and it is unclear whether this marker is predictive or prognostic.
Journal ArticleDOI
Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer (CheckMate 017 and CheckMate 057): 3-year update and outcomes in patients with liver metastases
Everett E. Vokes,Neal Ready,Enriqueta Felip,Leora Horn,Marco Angelo Burgio,S.J. Antonia,O. Aren Frontera,Scott N. Gettinger,Esther Holgado,David R. Spigel,David M. Waterhouse,Manuel Domine,Marina Chiara Garassino,Laura Q.M. Chow,George R. Blumenschein,Fabrice Barlesi,Bruno Coudert,Justin F. Gainor,Oscar Arrieta,Julie R. Brahmer,Charles Butts,Martin Steins,William J. Geese,Ang Li,Diane Healey,L. Crinò +25 more
TL;DR: In this article, the anti-programmed death-1 antibody nivolumab versus docetaxel was compared in patients with previously treated advanced squamous (CheckMate 017) and nonsquamous NSCLC.
References
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External review and validation of the Swedish national inpatient register
Jonas F. Ludvigsson,Jonas F. Ludvigsson,Eva Andersson,Anders Ekbom,Maria Feychting,Jeong-Lim Kim,Christina Reuterwall,Mona Heurgren,Petra Otterblad Olausson +8 more
TL;DR: The validity of the Swedish IPR is high for many but not all diagnoses, but for certain research areas the use of other health registers, such as the Swedish Cancer Register, may be more suitable.
Journal ArticleDOI
Metastasis to bone: causes, consequences and therapeutic opportunities
TL;DR: The most common human cancers — lung, breast and prostate — have a great avidity for bone, leading to painful and untreatable consequences.
Journal ArticleDOI
The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs
TL;DR: The most frequent target organs of metastasis are bone, brain, liver and the lung, and how tumor‐stromal interactions influence metastasis in each of these organs is discussed.
Journal ArticleDOI
Metastatic patterns in adenocarcinoma
Kenneth R. Hess,Gauri R. Varadhachary,Sarah H. Taylor,Wei Wei,Martin N. Raber,Renato Lenzi,James L. Abbruzzese +6 more
TL;DR: Clinical data was analyzed from a large number of patients with histologically confirmed, distant‐stage adenocarcinoma to evaluate metastatic patterns.
Journal ArticleDOI
Metastatic Patterns of Cancers: Results From a Large Autopsy Study
Guy diSibio,Samuel W. French +1 more
TL;DR: Not surprisingly, different primary cancers tended to metastasize, with differing frequencies, to different sites, which might be helpful in deducing the origins of cancers whose primary sites are unclear at presentation.
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