miR-196a Downregulation Increases the Expression of Type I and III Collagens in Keloid Fibroblasts
Kazuya Kashiyama,Norisato Mitsutake,Michiko Matsuse,Tomoo Ogi,Vladimir Saenko,Kenta Ujifuku,Atsushi Utani,Akiyoshi Hirano,Shunichi Yamashita +8 more
TLDR
It is demonstrated for the first time that miRNA expression profile is altered in KFs compared with normal fibroblasts, suggesting that miR-196a could be a new therapeutic target for keloid lesions.About:
This article is published in Journal of Investigative Dermatology.The article was published on 2012-06-01 and is currently open access. It has received 120 citations till now. The article focuses on the topics: Keloid & Fibroblast.read more
Citations
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Transition from inflammation to proliferation: a critical step during wound healing
TL;DR: This review summarizes mechanisms regulating the inflammation–proliferation transition at cellular and molecular levels and proposes that identification of such mechanisms will reveal promising targets for development of more effective therapies.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Recent Understandings of Biology, Prophylaxis and Treatment Strategies for Hypertrophic Scars and Keloids
Ho Jun Lee,Yong Ju Jang +1 more
TL;DR: The authors introduce and summarize classical concepts surrounding wound healing and review recent understandings of the biology, prevention and treatment strategies for hypertrophic scars and keloids.
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MicroRNA-99 Family Targets AKT/mTOR Signaling Pathway in Dermal Wound Healing
Yi Jin,Stéphanie D. Tymen,Dan Chen,Dan Chen,Zong Juan Fang,Yan Zhao,Dragan Dragas,Yang Dai,Phillip T. Marucha,Xiaofeng Zhou +9 more
TL;DR: Evidence that miR-99 family members contribute to wound healing by regulating the AKT/mTOR signaling is provided.
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MicroRNAs, transforming growth factor beta‐1, and tissue fibrosis
TL;DR: An overview of microRNA biology is provided with a focus on their emerging role in diseases typified by organ fibrosis, and a subset of these genes, including the key profibrotic cytokine transforming growth factor beta‐1, exhibits particularly strong levels of post‐transcriptional control of protein synthesis.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.