miR-27a-3p protects against blood–brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11
Tianyang Xi,Feng Jin,Ying Zhu,Jialu Wang,Ling Tang,Yanzhe Wang,David S Liebeskind,Fabien Scalzo,Zhiyi He +8 more
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TLDR
It is concluded that application of exogenous miR-27a-3p may protect against post-ICH complications by targeting AQP11 in the capillary endothelial cells of the brain.About:
This article is published in Journal of Biological Chemistry.The article was published on 2018-12-28 and is currently open access. It has received 79 citations till now. The article focuses on the topics: Blood–brain barrier & Intracerebral hemorrhage.read more
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MicroRNA based theranostics for brain cancer: basic principles
George E. D. Petrescu,George E. D. Petrescu,Alexandru A Sabo,Ligia I. Torsin,George A. Calin,Mihnea P. Dragomir +5 more
TL;DR: Because of the proven roles played by miRNAs in gliomagenesis and of their capacity to pass from the CNS tissue into the blood or cerebrospinal fluid (CSF), mi RNAs are proposed as ideal diagnostic and prognostic biomarkers.
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MicroRNAs in central nervous system diseases: A prospective role in regulating blood-brain barrier integrity.
TL;DR: Evidence presented in this review will encourage a deeper understanding of the mechanisms by which miRNAs regulate BBB function, and facilitate the development of new mi RNAs-based therapies in patients with CNS diseases.
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AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis
José Luis Trillo-Contreras,José Luis Trillo-Contreras,Juan José Toledo-Aral,Juan José Toledo-Aral,Miriam Echevarría,Miriam Echevarría,Javier Villadiego,Javier Villadiego +7 more
TL;DR: The data reported here indicate a significant extra-choroidal CSF formation mediated by AQP4, supporting the idea of an important and constant CSF production/absorption process, sustained by efflux/influx of water between brain capillaries and interstitial fluid.
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Epigenetic mechanisms of neurodegenerative diseases and acute brain injury
TL;DR: This review aims to highlight ways in which epigenetics applies to several commonly researched neurodegenerative diseases and forms of acute brain injury as well as shed light on the benefits of epigenetics-based treatments.
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Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury.
TL;DR: It is demonstrated that DEX inhibits inflammatory response and autophagy involved in TBI in vivo through inactivation of the circLrp1b/miR-27a-3p/Dram2 signaling pathway.
References
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Shusheng Wang,Arin B. Aurora,Brett A. Johnson,Xiaoxia Qi,John McAnally,Joseph A. Hill,James A. Richardson,Rhonda S Bassel-Duby,Eric N. Olson +8 more
TL;DR: It is shown that an endothelial cell-restricted microRNA (miR-126) mediates developmental angiogenesis in vivo and enhances the proangiogenic actions of VEGF and FGF and promotes blood vessel formation by repressing the expression of Spred-1, an intracellular inhibitor of angiogenic signaling.
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Adnan I. Qureshi,Adnan I. Qureshi,Stanley Tuhrim,Joseph P. Broderick,H. Hunt Batjer,Hideki Hondo,Daniel F. Hanley +6 more
TL;DR: Nontraumatic intracerebral hemorrhage is bleeding into the parenchyma of the brain that may extend into the ventricles and, in rare cases, the subarachnoid space.
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Mechanisms of brain injury after intracerebral haemorrhage
TL;DR: The coagulation cascade, haemoglobin breakdown products, and inflammation all play a part in ICH-induced injury and could provide new therapeutic targets and new therapeutic interventions for this severe form of stroke.
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Illuminating the silence: understanding the structure and function of small RNAs.
TL;DR: Understanding the structure and function of small RNAs, such as siRNAs and miRNAs, that trigger RNAi has shed light on the RNAi machinery and provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi.